Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactine secretino by serotonin agonists

Miljana Simonovic; Herbert Y. Meltzer

doi:10.1016/0014-2999(79)90310-8

Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactine secretino by serotonin agonists

Miljana Simonovic^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.

Original language	English (US)
Pages (from-to)	399-405
Number of pages	7
Journal	European Journal of Pharmacology
Volume	58
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(79)90310-8
State	Published - Oct 15 1979

Keywords

5-Methoxy-M,N-dimethyltryptamine
Prolactin
Serotonin agonist
Supersensitivity

ASJC Scopus subject areas

Pharmacology

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title = "Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactine secretino by serotonin agonists",

abstract = "Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.",

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AU - Meltzer, Herbert Y.

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N2 - Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.

AB - Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.

KW - 5-Methoxy-M,N-dimethyltryptamine

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KW - Serotonin agonist

KW - Supersensitivity

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