TY - JOUR
T1 - Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactine secretino by serotonin agonists
AU - Simonovic, Miljana
AU - Meltzer, Herbert Y.
N1 - Funding Information:
This researchw as supportedin part by USPHS MH 30,938, MH 29,206 and RCSAMH 47,808 to HYM and by the State of Illinois, Departmenot f Mental Healtha ndby PSH MH 14,274t o MS.
PY - 1979/10/15
Y1 - 1979/10/15
N2 - Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.
AB - Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.
KW - 5-Methoxy-M,N-dimethyltryptamine
KW - Prolactin
KW - Serotonin agonist
KW - Supersensitivity
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U2 - 10.1016/0014-2999(79)90310-8
DO - 10.1016/0014-2999(79)90310-8
M3 - Article
C2 - 510375
AN - SCOPUS:0018595998
SN - 0014-2999
VL - 58
SP - 399
EP - 405
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 4
ER -