Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactine secretino by serotonin agonists

Miljana Simonovic*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Repeated administration of 5-methoxy-N,N-demethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalEuropean Journal of Pharmacology
Volume58
Issue number4
DOIs
StatePublished - Oct 15 1979

Keywords

  • 5-Methoxy-M,N-dimethyltryptamine
  • Prolactin
  • Serotonin agonist
  • Supersensitivity

ASJC Scopus subject areas

  • Pharmacology

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