Abstract
Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.
Original language | English (US) |
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Pages (from-to) | 79.e1-79.e5 |
Journal | American journal of obstetrics and gynecology |
Volume | 205 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2011 |
Funding
Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27917 , HD27860 , HD27915 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD36801 ) and M01-RR-000080 from the National Center for Research Resources .
Keywords
- antenatal corticosteroids
- gene polymorphisms
- inflammation
- interleukin-6
- neurodevelopmental delay
ASJC Scopus subject areas
- Obstetrics and Gynecology