Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

Erin A.S. Clark; Lisa Mele; Ronald J. Wapner; Catherine Y. Spong; Yoram Sorokin; Alan Peaceman; Jay D. Iams; Kenneth J. Leveno; Margaret Harper; Steve N. Caritis; Brian M. Mercer; John M. Thorp; Susan M. Ramin; Marshall Carpenter; Dwight J. Rouse

doi:10.1016/j.ajog.2011.02.061

Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

Erin A.S. Clark^*, Lisa Mele, Ronald J. Wapner, Catherine Y. Spong, Yoram Sorokin, Alan Peaceman, Jay D. Iams, Kenneth J. Leveno, Margaret Harper, Steve N. Caritis, Brian M. Mercer, John M. Thorp, Susan M. Ramin, Marshall Carpenter, Dwight J. Rouse

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.

Original language	English (US)
Pages (from-to)	79.e1-79.e5
Journal	American journal of obstetrics and gynecology
Volume	205
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2011.02.061
State	Published - Jul 2011

Funding

Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27917 , HD27860 , HD27915 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD36801 ) and M01-RR-000080 from the National Center for Research Resources .

Keywords

antenatal corticosteroids
gene polymorphisms
inflammation
interleukin-6
neurodevelopmental delay

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2011.02.061

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Clark, E. A. S., Mele, L., Wapner, R. J., Spong, C. Y., Sorokin, Y., Peaceman, A., Iams, J. D., Leveno, K. J., Harper, M., Caritis, S. N., Mercer, B. M., Thorp, J. M., Ramin, S. M., Carpenter, M., & Rouse, D. J. (2011). Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2. American journal of obstetrics and gynecology, 205(1), 79.e1-79.e5. https://doi.org/10.1016/j.ajog.2011.02.061

@article{42c57ef9a4e44f7bb26eca142ddadc54,

title = "Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2",

abstract = "Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.",

keywords = "antenatal corticosteroids, gene polymorphisms, inflammation, interleukin-6, neurodevelopmental delay",

author = "Clark, {Erin A.S.} and Lisa Mele and Wapner, {Ronald J.} and Spong, {Catherine Y.} and Yoram Sorokin and Alan Peaceman and Iams, {Jay D.} and Leveno, {Kenneth J.} and Margaret Harper and Caritis, {Steve N.} and Mercer, {Brian M.} and Thorp, {John M.} and Ramin, {Susan M.} and Marshall Carpenter and Rouse, {Dwight J.}",

note = "Funding Information: Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27917 , HD27860 , HD27915 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD36801 ) and M01-RR-000080 from the National Center for Research Resources . ",

year = "2011",

month = jul,

doi = "10.1016/j.ajog.2011.02.061",

language = "English (US)",

volume = "205",

pages = "79.e1--79.e5",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Elsevier Inc.",

number = "1",

}

Clark, EAS, Mele, L, Wapner, RJ, Spong, CY, Sorokin, Y, Peaceman, A, Iams, JD, Leveno, KJ, Harper, M, Caritis, SN, Mercer, BM, Thorp, JM, Ramin, SM, Carpenter, M & Rouse, DJ 2011, 'Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2', American journal of obstetrics and gynecology, vol. 205, no. 1, pp. 79.e1-79.e5. https://doi.org/10.1016/j.ajog.2011.02.061

TY - JOUR

T1 - Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

AU - Clark, Erin A.S.

AU - Mele, Lisa

AU - Wapner, Ronald J.

AU - Spong, Catherine Y.

AU - Sorokin, Yoram

AU - Peaceman, Alan

AU - Iams, Jay D.

AU - Leveno, Kenneth J.

AU - Harper, Margaret

AU - Caritis, Steve N.

AU - Mercer, Brian M.

AU - Thorp, John M.

AU - Ramin, Susan M.

AU - Carpenter, Marshall

AU - Rouse, Dwight J.

N1 - Funding Information: Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27917 , HD27860 , HD27915 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD36801 ) and M01-RR-000080 from the National Center for Research Resources .

PY - 2011/7

Y1 - 2011/7

N2 - Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.

AB - Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years. Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years. Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.8622.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.483.54). Results were unchanged after controlling for potential confounders. Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 174 GG genotype.

KW - antenatal corticosteroids

KW - gene polymorphisms

KW - inflammation

KW - interleukin-6

KW - neurodevelopmental delay

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SN - 0002-9378

VL - 205

SP - 79.e1-79.e5

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

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ER -

Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2

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