Reported gastroparesis in adults with type 1 diabetes (T1D) from the T1D Exchange clinic registry

for the T1D Exchange Clinic Network

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective To better understand the prevalence and impact of gastroparesis in the T1D Exchange clinic registry database. Methods The analysis included 7107 adult participants with T1D across 45 sites (median age 46 years. and median duration 24 years). Linear and logistic regression models were used to assess the association of gastroparesis vs. no gastroparesis (obtained from medical record) with demographic characteristics, glycemic control and diabetes complications. Results Among 7107 registry participants, 340 (4.8%) had a clinical diagnosis of gastroparesis. Females were more likely to have gastroparesis compared with males (5.8% vs. 3.5%, P < 0.001). Participants with gastroparesis compared with those without gastroparesis were older (median age 49.4 vs. 45.3 years, P < 0.001), had a longer duration of T1D (median duration 32 vs. 23 years, P < 0.001), higher mean HbA1c (8.1% vs. 7.7% [65 vs. 61 mmol/mol], P < 0.001), more frequent severe hypoglycemia (25% vs. 11% with ≥ 1 event in the past 12 months, P < 0.001), lower socio-economic status, less likely to be using CGM and insulin pump and greater prevalence of microvascular and neuropathic complications than participants without gastroparesis. Conclusion Gastroparesis is associated with higher risk of severe hypoglycemia despite higher HbA1c levels than in T1D patients without gastroparesis. The increased presence of multiple long-term complications and overall poor glycemic control in these subjects emphasizes the need to establish diagnostic protocols for earlier diagnosis, achieve tighter glycemic control with more extensive use of insulin pumps and continuous glucose monitoring, and the need for wider availability of medical therapies for treatment of diabetic gastroparesis.

Original languageEnglish (US)
Pages (from-to)1669-1673
Number of pages5
JournalJournal of Diabetes and Its Complications
Volume31
Issue number12
DOIs
StatePublished - Dec 2017

Keywords

  • Adult
  • Complications
  • Diabetes management
  • Gastroparesis
  • Glycemic control
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Reported gastroparesis in adults with type 1 diabetes (T1D) from the T1D Exchange clinic registry'. Together they form a unique fingerprint.

Cite this