Reproductive factors and risks of biliary tract cancers and stones: A population-based study in Shanghai, China

G. Andreotti; L. Hou; Y. T. Gao; L. A. Brinton; A. Rashid; J. Chen; M. C. Shen; B. S. Wang; T. Q. Han; B. H. Zhang; L. C. Sakoda; J. F. Fraumeni; A. W. Hsing

doi:10.1038/sj.bjc.6605597

Reproductive factors and risks of biliary tract cancers and stones: A population-based study in Shanghai, China

G. Andreotti^*, L. Hou, Y. T. Gao, L. A. Brinton, A. Rashid, J. Chen, M. C. Shen, B. S. Wang, T. Q. Han, B. H. Zhang, L. C. Sakoda, J. F. Fraumeni, A. W. Hsing

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.Results:The effects of parity (odds ratios, OR_{3 vs 1 child}= 2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR _{per 1-year decrease}= 1.2, 95% CI 0.99-1.6), and older age at menarche (OR _{per 1-year increase}= 1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.

Original language	English (US)
Pages (from-to)	1185-1189
Number of pages	5
Journal	British Journal of Cancer
Volume	102
Issue number	7
DOIs	https://doi.org/10.1038/sj.bjc.6605597
State	Published - Mar 2010

Funding

We thank Jiarong Cheng, Lu Sun, Kai Wu, Enju Liu, and Xuehong Zhang, as well as the staff at the Shanghai Cancer Institute, for data collection, specimen collection, and processing; the surgeons at the collaborating hospitals for data collection; the local pathologists for pathology review; and Hope Webb-Cohen and Shelley Niwa of Westat for data preparation and management. This research was supported by the Intramural Research Programme of the National Institutes of Health, National Cancer Institute.

Keywords

Biliary tract cancer
Gallstones
Reproductive factors

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605597

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Andreotti, G., Hou, L., Gao, Y. T., Brinton, L. A., Rashid, A., Chen, J., Shen, M. C., Wang, B. S., Han, T. Q., Zhang, B. H., Sakoda, L. C., Fraumeni, J. F., & Hsing, A. W. (2010). Reproductive factors and risks of biliary tract cancers and stones: A population-based study in Shanghai, China. British Journal of Cancer, 102(7), 1185-1189. https://doi.org/10.1038/sj.bjc.6605597

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title = "Reproductive factors and risks of biliary tract cancers and stones: A population-based study in Shanghai, China",

abstract = "Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.Results:The effects of parity (odds ratios, OR3 vs 1 child= 2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR per 1-year decrease= 1.2, 95% CI 0.99-1.6), and older age at menarche (OR per 1-year increase= 1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.",

keywords = "Biliary tract cancer, Gallstones, Reproductive factors",

author = "G. Andreotti and L. Hou and Gao, {Y. T.} and Brinton, {L. A.} and A. Rashid and J. Chen and Shen, {M. C.} and Wang, {B. S.} and Han, {T. Q.} and Zhang, {B. H.} and Sakoda, {L. C.} and Fraumeni, {J. F.} and Hsing, {A. W.}",

note = "Funding Information: We thank Jiarong Cheng, Lu Sun, Kai Wu, Enju Liu, and Xuehong Zhang, as well as the staff at the Shanghai Cancer Institute, for data collection, specimen collection, and processing; the surgeons at the collaborating hospitals for data collection; the local pathologists for pathology review; and Hope Webb-Cohen and Shelley Niwa of Westat for data preparation and management. This research was supported by the Intramural Research Programme of the National Institutes of Health, National Cancer Institute.",

year = "2010",

month = mar,

doi = "10.1038/sj.bjc.6605597",

language = "English (US)",

volume = "102",

pages = "1185--1189",

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T1 - Reproductive factors and risks of biliary tract cancers and stones

T2 - A population-based study in Shanghai, China

AU - Andreotti, G.

AU - Hou, L.

AU - Gao, Y. T.

AU - Brinton, L. A.

AU - Rashid, A.

AU - Chen, J.

AU - Shen, M. C.

AU - Wang, B. S.

AU - Han, T. Q.

AU - Zhang, B. H.

AU - Sakoda, L. C.

AU - Fraumeni, J. F.

AU - Hsing, A. W.

N1 - Funding Information: We thank Jiarong Cheng, Lu Sun, Kai Wu, Enju Liu, and Xuehong Zhang, as well as the staff at the Shanghai Cancer Institute, for data collection, specimen collection, and processing; the surgeons at the collaborating hospitals for data collection; the local pathologists for pathology review; and Hope Webb-Cohen and Shelley Niwa of Westat for data preparation and management. This research was supported by the Intramural Research Programme of the National Institutes of Health, National Cancer Institute.

PY - 2010/3

Y1 - 2010/3

N2 - Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.Results:The effects of parity (odds ratios, OR3 vs 1 child= 2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR per 1-year decrease= 1.2, 95% CI 0.99-1.6), and older age at menarche (OR per 1-year increase= 1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.

AB - Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.Results:The effects of parity (odds ratios, OR3 vs 1 child= 2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR per 1-year decrease= 1.2, 95% CI 0.99-1.6), and older age at menarche (OR per 1-year increase= 1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.

KW - Biliary tract cancer

KW - Gallstones

KW - Reproductive factors

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Reproductive factors and risks of biliary tract cancers and stones: A population-based study in Shanghai, China

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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