Abstract
Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.Results:The effects of parity (odds ratios, OR3 vs 1 child= 2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR per 1-year decrease= 1.2, 95% CI 0.99-1.6), and older age at menarche (OR per 1-year increase= 1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.
Original language | English (US) |
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Pages (from-to) | 1185-1189 |
Number of pages | 5 |
Journal | British Journal of Cancer |
Volume | 102 |
Issue number | 7 |
DOIs | |
State | Published - Mar 2010 |
Funding
We thank Jiarong Cheng, Lu Sun, Kai Wu, Enju Liu, and Xuehong Zhang, as well as the staff at the Shanghai Cancer Institute, for data collection, specimen collection, and processing; the surgeons at the collaborating hospitals for data collection; the local pathologists for pathology review; and Hope Webb-Cohen and Shelley Niwa of Westat for data preparation and management. This research was supported by the Intramural Research Programme of the National Institutes of Health, National Cancer Institute.
Keywords
- Biliary tract cancer
- Gallstones
- Reproductive factors
ASJC Scopus subject areas
- Oncology
- Cancer Research