Abstract
Interventions to assist reproductive health decision-making in populations affected by sickle cell disease (SCD) or trait (SCT) lack proven efficacy over time. Our aim was to compare effects of CHOICES, a Web-based multimedia education program on implementing informed reproductive plans, and usual care education (e-Book) on reproductive knowledge, intention, and behavior over 24 months. We randomized 234 participants with SCD (n = 138) or SCT (n = 96) (age 18–35 years, 35 % male, 94 % African American) to CHOICES and e-Book groups. Participants completed a sickle cell-specific reproductive measure before and four times after the intervention (6, 12, 18 and 24 months). Compared to the e-Book group the CHOICES group had significantly more improvement in knowledge over time (p =.004) but not intention (p =.18) or behavior (p =.69). At baseline, 114 (48.7 %) participants reported having partners who would not put the couple at risk for their children inheriting SCD. Of the 116 (49.6 %) at-risk participants, a higher poroportion of those who were in the CHOICES group chose partners that reduced their risk by the last visit than the e-Book group (p =.04). Study findings provide important insights for designing a national trial of the CHOICES intervention focusing on subjects whose partner status puts them at risk for having a child with SCD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 325-336 |
| Number of pages | 12 |
| Journal | Journal of Genetic Counseling |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Longitudinal follow-up
- Randomized controlled trial
- Reproductive behavior
- Sickle cell disease
- Sickle cell trait
- Young adult
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
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Reproductive Health CHOICES for Young Adults with Sickle Cell Disease or Trait : Randomized Controlled Trial Outcomes over Two Years. / Gallo, Agatha M.; Wilkie, Diana J.; Yao, Yingwei; Molokie, Robert E.; Stahl, Christiane; Hershberger, Patricia E.; Zhao, Zhongsheng; Suarez, Marie L.; Johnson, Bonnye; Angulo, Rigoberto; Carrasco, Jesus; Angulo, Veronica; Thompson, Alexis A.
In: Journal of Genetic Counseling, Vol. 25, No. 2, 01.04.2016, p. 325-336.Research output: Contribution to journal › Article
TY - JOUR
T1 - Reproductive Health CHOICES for Young Adults with Sickle Cell Disease or Trait
T2 - Randomized Controlled Trial Outcomes over Two Years
AU - Gallo, Agatha M.
AU - Wilkie, Diana J.
AU - Yao, Yingwei
AU - Molokie, Robert E.
AU - Stahl, Christiane
AU - Hershberger, Patricia E.
AU - Zhao, Zhongsheng
AU - Suarez, Marie L.
AU - Johnson, Bonnye
AU - Angulo, Rigoberto
AU - Carrasco, Jesus
AU - Angulo, Veronica
AU - Thompson, Alexis A
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Interventions to assist reproductive health decision-making in populations affected by sickle cell disease (SCD) or trait (SCT) lack proven efficacy over time. Our aim was to compare effects of CHOICES, a Web-based multimedia education program on implementing informed reproductive plans, and usual care education (e-Book) on reproductive knowledge, intention, and behavior over 24 months. We randomized 234 participants with SCD (n = 138) or SCT (n = 96) (age 18–35 years, 35 % male, 94 % African American) to CHOICES and e-Book groups. Participants completed a sickle cell-specific reproductive measure before and four times after the intervention (6, 12, 18 and 24 months). Compared to the e-Book group the CHOICES group had significantly more improvement in knowledge over time (p =.004) but not intention (p =.18) or behavior (p =.69). At baseline, 114 (48.7 %) participants reported having partners who would not put the couple at risk for their children inheriting SCD. Of the 116 (49.6 %) at-risk participants, a higher poroportion of those who were in the CHOICES group chose partners that reduced their risk by the last visit than the e-Book group (p =.04). Study findings provide important insights for designing a national trial of the CHOICES intervention focusing on subjects whose partner status puts them at risk for having a child with SCD.
AB - Interventions to assist reproductive health decision-making in populations affected by sickle cell disease (SCD) or trait (SCT) lack proven efficacy over time. Our aim was to compare effects of CHOICES, a Web-based multimedia education program on implementing informed reproductive plans, and usual care education (e-Book) on reproductive knowledge, intention, and behavior over 24 months. We randomized 234 participants with SCD (n = 138) or SCT (n = 96) (age 18–35 years, 35 % male, 94 % African American) to CHOICES and e-Book groups. Participants completed a sickle cell-specific reproductive measure before and four times after the intervention (6, 12, 18 and 24 months). Compared to the e-Book group the CHOICES group had significantly more improvement in knowledge over time (p =.004) but not intention (p =.18) or behavior (p =.69). At baseline, 114 (48.7 %) participants reported having partners who would not put the couple at risk for their children inheriting SCD. Of the 116 (49.6 %) at-risk participants, a higher poroportion of those who were in the CHOICES group chose partners that reduced their risk by the last visit than the e-Book group (p =.04). Study findings provide important insights for designing a national trial of the CHOICES intervention focusing on subjects whose partner status puts them at risk for having a child with SCD.
KW - Longitudinal follow-up
KW - Randomized controlled trial
KW - Reproductive behavior
KW - Sickle cell disease
KW - Sickle cell trait
KW - Young adult
UR - http://www.scopus.com/inward/record.url?scp=84961201000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961201000&partnerID=8YFLogxK
U2 - 10.1007/s10897-015-9874-0
DO - 10.1007/s10897-015-9874-0
M3 - Article
VL - 25
SP - 325
EP - 336
JO - Journal of Genetic Counseling
JF - Journal of Genetic Counseling
SN - 1059-7700
IS - 2
ER -