Abstract
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.
Original language | English (US) |
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Pages (from-to) | 246-255 |
Number of pages | 10 |
Journal | Nature Reviews Cancer |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2007 |
Funding
The authors would like to gratefully acknowledge the help of J. Topczewska, J. Topczewski, N. Margaryan, A. Hess and B. Nickoloff. This research was supported by a grant from the National Cancer Institute.
ASJC Scopus subject areas
- Oncology
- Cancer Research