Reprogramming metastatic tumour cells with embryonic microenvironments

Mary J.C. Hendrix*, Elisabeth A. Seftor, Richard E.B. Seftor, Jennifer Kasemeier-Kulesa, Paul M. Kulesa, Lynne Marie Postovit

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

398 Scopus citations


Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalNature Reviews Cancer
Issue number4
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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