Reprogramming metastatic tumour cells with embryonic microenvironments

Mary J.C. Hendrix; Elisabeth A. Seftor; Richard E.B. Seftor; Jennifer Kasemeier-Kulesa; Paul M. Kulesa; Lynne Marie Postovit

doi:10.1038/nrc2108

Reprogramming metastatic tumour cells with embryonic microenvironments

Mary J.C. Hendrix^*, Elisabeth A. Seftor, Richard E.B. Seftor, Jennifer Kasemeier-Kulesa, Paul M. Kulesa, Lynne Marie Postovit

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

388 Scopus citations

Abstract

Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.

Original language	English (US)
Pages (from-to)	246-255
Number of pages	10
Journal	Nature Reviews Cancer
Volume	7
Issue number	4
DOIs	https://doi.org/10.1038/nrc2108
State	Published - Apr 2007

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Reprogramming metastatic tumour cells with embryonic microenvironments",

abstract = "Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.",

author = "Hendrix, {Mary J.C.} and Seftor, {Elisabeth A.} and Seftor, {Richard E.B.} and Jennifer Kasemeier-Kulesa and Kulesa, {Paul M.} and Postovit, {Lynne Marie}",

note = "Funding Information: The authors would like to gratefully acknowledge the help of J. Topczewska, J. Topczewski, N. Margaryan, A. Hess and B. Nickoloff. This research was supported by a grant from the National Cancer Institute.",

year = "2007",

month = apr,

doi = "10.1038/nrc2108",

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AU - Hendrix, Mary J.C.

AU - Seftor, Elisabeth A.

AU - Seftor, Richard E.B.

AU - Kasemeier-Kulesa, Jennifer

AU - Kulesa, Paul M.

AU - Postovit, Lynne Marie

N1 - Funding Information: The authors would like to gratefully acknowledge the help of J. Topczewska, J. Topczewski, N. Margaryan, A. Hess and B. Nickoloff. This research was supported by a grant from the National Cancer Institute.

PY - 2007/4

Y1 - 2007/4

N2 - Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.

AB - Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.

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Reprogramming metastatic tumour cells with embryonic microenvironments

Abstract

ASJC Scopus subject areas

UN SDGs

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