Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report

Carmen Mikacenic; D. Clark Files; Francis Almonor; Jasmine Bell; Ellen L. Burnham; Linda L. Chlan; Sarah K. Cook; Robert P. Dickson; Lynn A. Fussner; Fengming Luo; Karan Madan; Luisa Morales-Nebreda; Kara J. Mould; A. John Simpson; Benjamin D. Singer; Renee D. Stapleton; Chris H. Wendt

doi:10.1513/AnnalsATS.202302-106ST

Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report

Carmen Mikacenic^*, D. Clark Files, Francis Almonor, Jasmine Bell, Ellen L. Burnham, Linda L. Chlan, Sarah K. Cook, Robert P. Dickson, Lynn A. Fussner, Fengming Luo, Karan Madan, Luisa Morales-Nebreda, Kara J. Mould, A. John Simpson, Benjamin D. Singer, Renee D. Stapleton, Chris H. Wendt

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Bronchoscopy for research purposes is a valuable tool to understand lung-specific biology in human participants. Despite published reports and active research protocols using this procedure in critically ill patients, no recent document encapsulates the important safety considerations and downstream applications of this procedure in this setting. The objectives were to identify safe practices for patient selection and protection of hospital staff, provide recommendations for sample procurement to standardize studies, and give guidance on sample preparation for novel research technologies. Seventeen international experts in the management of critically ill patients, bronchoscopy in clinical and research settings, and experience in patient-oriented clinical or translational research convened for a workshop. Review of relevant literature, expert presentations, and discussion generated the findings presented herein. The committee concludes that research bronchoscopy with bronchoalveolar lavage in critically ill patients on mechanical ventilation is valuable and safe in appropriately selected patients. This report includes recommendations on standardization of this procedure and prioritizes the reporting of sample management to produce more reproducible results between laboratories. This document serves as a resource to the community of researchers who endeavor to include bronchoscopy as part of their research protocols and highlights key considerations for the inclusion and safety of research participants.

Original language	English (US)
Pages (from-to)	621-631
Number of pages	11
Journal	Annals of the American Thoracic Society
Volume	20
Issue number	5
DOIs	https://doi.org/10.1513/AnnalsATS.202302-106ST
State	Published - May 2023

Funding

Chicago, Illinois; 14Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; 15Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; 16Department of Respiratory Medicine, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; 20Division of Pulmonary and Critical Care Medicine, Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont; 21Pulmonary, Allergy, Critical Care, and Sleep Medicine Section, University of Minnesota, Minneapolis, Minnesota; and 22Minneapolis Veterans Affairs Medical Center (VAMC), Minneapolis, Minnesota Author Disclosures: E.L.B. received research support from Humanetics, NIH/NIAAA, and Quantum Leap Healthcare. R.P.D. served on advisory committee for Prevada Medical; has financial stake in Sequal. K.J.M. received research support from NIH. A.J.S. received research support from Aerogen, Becton Dickinson Biosciences, and Partner Therapeutics. B.D.S. served on scientific advisory board for Zoe Biosciences; holds patent no. US 10,905,706 B2; received research support from NIH. R.D.S. served on data safety and monitoring board for Altimmune; served as consultant for CSL Behring. D.C.F. served on data safety and monitoring board for Medpace; served as consultant for Cytovale and Global Blood Therapeutics; received research support from NIH. C.M., L.A.F., J.B., L.L.C., S.K.C., F.A., F.L., K.M., L.M.-N., and C.H.W. reported no commercial or relevant non-commercial interests from ineligible companies. This document was funded by the American Thoracic Society. The views expressed in this article are those of the authors and do not reflect the views of the United States Government, the Department of Veterans Affairs, the funders, the sponsors, or any of the authors’ affiliated academic institutions. A.J.S. is a National Institute for Health Research Senior Investigator. The views expressed in this article are those of the author(s) and not necessarily those of the National Institute for Health Research or the Department of Health and Social Care.

Keywords

acute respiratory distress syndrome
bronchoscopy
critical illness
respiratory failure
ventilator-associated pneumonia

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1513/AnnalsATS.202302-106ST

Cite this

Mikacenic, C., Files, D. C., Almonor, F., Bell, J., Burnham, E. L., Chlan, L. L., Cook, S. K., Dickson, R. P., Fussner, L. A., Luo, F., Madan, K., Morales-Nebreda, L., Mould, K. J., Simpson, A. J., Singer, B. D., Stapleton, R. D., & Wendt, C. H. (2023). Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report. Annals of the American Thoracic Society, 20(5), 621-631. https://doi.org/10.1513/AnnalsATS.202302-106ST

@article{b690728edd6540ea98352fb817a64c86,

title = "Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report",

abstract = "Bronchoscopy for research purposes is a valuable tool to understand lung-specific biology in human participants. Despite published reports and active research protocols using this procedure in critically ill patients, no recent document encapsulates the important safety considerations and downstream applications of this procedure in this setting. The objectives were to identify safe practices for patient selection and protection of hospital staff, provide recommendations for sample procurement to standardize studies, and give guidance on sample preparation for novel research technologies. Seventeen international experts in the management of critically ill patients, bronchoscopy in clinical and research settings, and experience in patient-oriented clinical or translational research convened for a workshop. Review of relevant literature, expert presentations, and discussion generated the findings presented herein. The committee concludes that research bronchoscopy with bronchoalveolar lavage in critically ill patients on mechanical ventilation is valuable and safe in appropriately selected patients. This report includes recommendations on standardization of this procedure and prioritizes the reporting of sample management to produce more reproducible results between laboratories. This document serves as a resource to the community of researchers who endeavor to include bronchoscopy as part of their research protocols and highlights key considerations for the inclusion and safety of research participants.",

keywords = "acute respiratory distress syndrome, bronchoscopy, critical illness, respiratory failure, ventilator-associated pneumonia",

author = "Carmen Mikacenic and Files, {D. Clark} and Francis Almonor and Jasmine Bell and Burnham, {Ellen L.} and Chlan, {Linda L.} and Cook, {Sarah K.} and Dickson, {Robert P.} and Fussner, {Lynn A.} and Fengming Luo and Karan Madan and Luisa Morales-Nebreda and Mould, {Kara J.} and Simpson, {A. John} and Singer, {Benjamin D.} and Stapleton, {Renee D.} and Wendt, {Chris H.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 by the American Thoracic Society.",

year = "2023",

month = may,

doi = "10.1513/AnnalsATS.202302-106ST",

language = "English (US)",

volume = "20",

pages = "621--631",

journal = "Annals of the American Thoracic Society",

issn = "2329-6933",

publisher = "American Thoracic Society",

number = "5",

}

Mikacenic, C, Files, DC, Almonor, F, Bell, J, Burnham, EL, Chlan, LL, Cook, SK, Dickson, RP, Fussner, LA, Luo, F, Madan, K, Morales-Nebreda, L, Mould, KJ, Simpson, AJ, Singer, BD, Stapleton, RD & Wendt, CH 2023, 'Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report', Annals of the American Thoracic Society, vol. 20, no. 5, pp. 621-631. https://doi.org/10.1513/AnnalsATS.202302-106ST

TY - JOUR

T1 - Research Bronchoscopies in Critically Ill Research Participants

T2 - An Official American Thoracic Society Workshop Report

AU - Mikacenic, Carmen

AU - Files, D. Clark

AU - Almonor, Francis

AU - Bell, Jasmine

AU - Burnham, Ellen L.

AU - Chlan, Linda L.

AU - Cook, Sarah K.

AU - Dickson, Robert P.

AU - Fussner, Lynn A.

AU - Luo, Fengming

AU - Madan, Karan

AU - Morales-Nebreda, Luisa

AU - Mould, Kara J.

AU - Simpson, A. John

AU - Singer, Benjamin D.

AU - Stapleton, Renee D.

AU - Wendt, Chris H.

PY - 2023/5

Y1 - 2023/5

N2 - Bronchoscopy for research purposes is a valuable tool to understand lung-specific biology in human participants. Despite published reports and active research protocols using this procedure in critically ill patients, no recent document encapsulates the important safety considerations and downstream applications of this procedure in this setting. The objectives were to identify safe practices for patient selection and protection of hospital staff, provide recommendations for sample procurement to standardize studies, and give guidance on sample preparation for novel research technologies. Seventeen international experts in the management of critically ill patients, bronchoscopy in clinical and research settings, and experience in patient-oriented clinical or translational research convened for a workshop. Review of relevant literature, expert presentations, and discussion generated the findings presented herein. The committee concludes that research bronchoscopy with bronchoalveolar lavage in critically ill patients on mechanical ventilation is valuable and safe in appropriately selected patients. This report includes recommendations on standardization of this procedure and prioritizes the reporting of sample management to produce more reproducible results between laboratories. This document serves as a resource to the community of researchers who endeavor to include bronchoscopy as part of their research protocols and highlights key considerations for the inclusion and safety of research participants.

AB - Bronchoscopy for research purposes is a valuable tool to understand lung-specific biology in human participants. Despite published reports and active research protocols using this procedure in critically ill patients, no recent document encapsulates the important safety considerations and downstream applications of this procedure in this setting. The objectives were to identify safe practices for patient selection and protection of hospital staff, provide recommendations for sample procurement to standardize studies, and give guidance on sample preparation for novel research technologies. Seventeen international experts in the management of critically ill patients, bronchoscopy in clinical and research settings, and experience in patient-oriented clinical or translational research convened for a workshop. Review of relevant literature, expert presentations, and discussion generated the findings presented herein. The committee concludes that research bronchoscopy with bronchoalveolar lavage in critically ill patients on mechanical ventilation is valuable and safe in appropriately selected patients. This report includes recommendations on standardization of this procedure and prioritizes the reporting of sample management to produce more reproducible results between laboratories. This document serves as a resource to the community of researchers who endeavor to include bronchoscopy as part of their research protocols and highlights key considerations for the inclusion and safety of research participants.

KW - acute respiratory distress syndrome

KW - bronchoscopy

KW - critical illness

KW - respiratory failure

KW - ventilator-associated pneumonia

UR - http://www.scopus.com/inward/record.url?scp=85159253878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85159253878&partnerID=8YFLogxK

U2 - 10.1513/AnnalsATS.202302-106ST

DO - 10.1513/AnnalsATS.202302-106ST

M3 - Article

C2 - 37125997

AN - SCOPUS:85159253878

SN - 2329-6933

VL - 20

SP - 621

EP - 631

JO - Annals of the American Thoracic Society

JF - Annals of the American Thoracic Society

IS - 5

ER -

Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this