Reserpine and Breast Cancer: A Community-Based Longitudinal Study of 2,000 Hypertensive Women

Darwin R. Labarthe, W. Michael O'Fallon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

To supplement several case-control studies questioning whether use of reserpine is associated with occurrence of breast cancer, we conducted a longitudinal study of nearly 2,000 hypertensive women residing in Rochester, Minn. Exposure to antihypertensive agents and subsequent incidence of breast cancer were ascertained. Expected numbers of cases, derived from local population data and from the Connecticut Tumor Registry, were compared with the numbers of cases observed in exposure groups of interest. No evidence was found of any association of reserpine use, thiazide use, or untreated hypertension with subsequent occurrence of breast cancer in these hypertensive women. In addition, several issues were investigated that warrant consideration in evaluating reports published to date, especially before conclusions are drawn as to the questionable contention that reserpine has caused breast cancer in women. (JAMA 243:2304-2310, 1980).

Original languageEnglish (US)
Pages (from-to)2304-2310
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Volume243
Issue number22
DOIs
StatePublished - Jun 13 1980

ASJC Scopus subject areas

  • Medicine(all)

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