Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback

Jonathan T. Reeder, Yeguang Xue, Daniel Franklin, Yujun Deng, Jungil Choi, Olivia Prado, Robin Kim, Claire Liu, Justin Hanson, John Ciraldo, Amay J. Bandodkar, Siddharth Krishnan, Alexandra Johnson, Emily Patnaude, Raudel Avila, Yonggang Huang, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Recently introduced classes of thin, soft, skin-mounted microfluidic systems offer powerful capabilities for continuous, real-time monitoring of total sweat loss, sweat rate and sweat biomarkers. Although these technologies operate without the cost, complexity, size, and weight associated with active components or power sources, rehydration events can render previous measurements irrelevant and detection of anomalous physiological events, such as high sweat loss, requires user engagement to observe colorimetric responses. Here we address these limitations through monolithic systems of pinch valves and suction pumps for purging of sweat as a reset mechanism to coincide with hydration events, microstructural optics for reversible readout of sweat loss, and effervescent pumps and chemesthetic agents for automated delivery of sensory warnings of excessive sweat loss. Human subject trials demonstrate the ability of these systems to alert users to the potential for dehydration via skin sensations initiated by sweat-triggered ejection of menthol and capsaicin.

Original languageEnglish (US)
Article number5513
JournalNature communications
Issue number1
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback'. Together they form a unique fingerprint.

Cite this