Residual functional connectivity in the split-brain revealed with resting-state functional MRI

Lucina Q. Uddin, Eric Mooshagian, Eran Zaidel, Anouk Scheres, Daniel S. Margulies, A. M Clare Kelly, Zarrar Shehzad, Jonathan S. Adelstein, F. Xavier Castellanos, Bharat B. Biswal, Michael P. Milham

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.

Original languageEnglish (US)
Pages (from-to)703-709
Number of pages7
JournalNeuroreport
Volume19
Issue number7
DOIs
StatePublished - May 2008

Keywords

  • Commissurotomy
  • Diffusion tensor imaging
  • Interhemispheric interaction
  • Laterality
  • Resting-state functional connectivity

ASJC Scopus subject areas

  • Neuroscience(all)

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