Resilience and White Matter Integrity in Geriatric Depression

Roza M. Vlasova, Prabha Siddarth, Beatrix Krause, Amber M. Leaver, Kelsey T. Laird, Natalie St Cyr, Katherine L. Narr, Helen Lavretsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objective: Greater psychological resilience may protect against developing depression in a growing geriatric population. Identifying the neural correlates of resilience in geriatric depression could provide neurobiologic targets to inform clinical interventions. However, most prior neuroimaging studies have only considered the presence or absence of resilience and have not addressed the multifactorial nature of resilience. The current study aimed to establish the neural correlates of four factors of resilience in the depressed elderly. Methods: White matter integrity was assessed using diffusion-weighted magnetic resonance imaging data collected from 70 older adults with major depressive disorder. We used four resilience factors previously derived in an exploratory factor analysis of the Connor-Davidson Resilience Scale in a large sample of depressed older adults: 1, grit; 2, active coping self-efficacy; 3, accommodative coping self-efficacy; and 4, spirituality. Results: The resilience factor “grit” was positively associated with fractional anisotropy in the callosal region connecting prefrontal cortex and fractional anisotropy in cingulum fibers; however, the latter did not survive correction for multiple comparisons. Conclusion: Structural integrity of major white matter pathways implicated in cognitive control and emotion regulation (i.e., connecting prefrontal cortex) was positively associated with the resilience factor “grit” in our sample of older adults with depression. Prospective studies are needed to determine the utility of the structural integrity of these pathways as a biomarker in predicting risk for depression and treatment response.

Original languageEnglish (US)
Pages (from-to)874-883
Number of pages10
JournalAmerican Journal of Geriatric Psychiatry
Issue number8
StatePublished - Aug 2018


  • Connor-Davidson Resilience Scale
  • DTI
  • MRI
  • White matter
  • geriatric depression
  • grit
  • major depressive disorder

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Resilience and White Matter Integrity in Geriatric Depression'. Together they form a unique fingerprint.

Cite this