Resistance strength training exercise in children with spinal muscular atrophy

Aga Lewelt; Kristin J. Krosschell; Gregory J. Stoddard; Cindy Weng; Mei Xue; Robin L. Marcus; Eduard Gappmaier; Louis Viollet; Barbara A. Johnson; Andrea T. White; Donata Viazzo-Trussell; Philippe Lopes; Robert H. Lane; John C. Carey; Kathryn J. Swoboda

doi:10.1002/mus.24568

Resistance strength training exercise in children with spinal muscular atrophy

Aga Lewelt^*, Kristin J. Krosschell, Gregory J. Stoddard, Cindy Weng, Mei Xue, Robin L. Marcus, Eduard Gappmaier, Louis Viollet, Barbara A. Johnson, Andrea T. White, Donata Viazzo-Trussell, Philippe Lopes, Robert H. Lane, John C. Carey, Kathryn J. Swoboda

^*Corresponding author for this work

Physical Therapy and Human Movement Sciences

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4±3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.

Original language	English (US)
Pages (from-to)	559-567
Number of pages	9
Journal	Muscle and Nerve
Volume	52
Issue number	4
DOIs	https://doi.org/10.1002/mus.24568
State	Published - Oct 1 2015

Keywords

Home-based exercise program
Neuromuscular disorder
Progressive resistance training exercise
Spinal muscular atrophy
Strength training exercise

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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Lewelt, A., Krosschell, K. J., Stoddard, G. J., Weng, C., Xue, M., Marcus, R. L., Gappmaier, E., Viollet, L., Johnson, B. A., White, A. T., Viazzo-Trussell, D., Lopes, P., Lane, R. H., Carey, J. C., & Swoboda, K. J. (2015). Resistance strength training exercise in children with spinal muscular atrophy. Muscle and Nerve, 52(4), 559-567. https://doi.org/10.1002/mus.24568

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abstract = "Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4±3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8\%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.",

keywords = "Home-based exercise program, Neuromuscular disorder, Progressive resistance training exercise, Spinal muscular atrophy, Strength training exercise",

author = "Aga Lewelt and Krosschell, \{Kristin J.\} and Stoddard, \{Gregory J.\} and Cindy Weng and Mei Xue and Marcus, \{Robin L.\} and Eduard Gappmaier and Louis Viollet and Johnson, \{Barbara A.\} and White, \{Andrea T.\} and Donata Viazzo-Trussell and Philippe Lopes and Lane, \{Robert H.\} and Carey, \{John C.\} and Swoboda, \{Kathryn J.\}",

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language = "English (US)",

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AU - Marcus, Robin L.

AU - Gappmaier, Eduard

AU - Viollet, Louis

AU - Johnson, Barbara A.

AU - White, Andrea T.

AU - Viazzo-Trussell, Donata

AU - Lopes, Philippe

AU - Lane, Robert H.

AU - Carey, John C.

AU - Swoboda, Kathryn J.

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N2 - Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4±3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.

AB - Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4±3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.

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Resistance strength training exercise in children with spinal muscular atrophy

Abstract

Keywords

ASJC Scopus subject areas

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