Resolution of aquaporin-4 antibodies in a woman with neuromyelitis optica treated with human autologous stem cell transplant

Patrick Aouad*, Jamma Li, Chris Arthur, Richard Burt, Suran Fernando, John Parratt

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We report a 47-year-old woman with highly active neuromyelitis optica (NMO) and persistent high titre anti-aquaporin-4 antibodies (anti-AQP-4) who was resistant to multiple immune therapies until she underwent autologous hematopoietic stem cell transplant (auto-HSCT). NMO is the only demyelinating disease with a clinically useful serum biomarker, aquaporin-4, a water channel protein expressed on astrocytes. Anti-AQP-4 antibodies correlate with NMO disease activity and animal models strongly suggest the antibody is pathogenic. Auto-HSCT was associated with clinical and radiological remission, improved disability and resolution of AQP-4 antibodies which are still undetectable 12 months later. The utility of auto-HSCT for refractory NMO warrants further investigation, particularly with regards to pre-conditioning regimens and the utility of AQP-4 antibodies as a biomarker for immunological and clinical remission.

Original languageEnglish (US)
Pages (from-to)1215-1217
Number of pages3
JournalJournal of Clinical Neuroscience
Volume22
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Antibodies
  • Aquaporin-4
  • Autologous hematopoietic stem cell transplant
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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