Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis

Dushyant V. Patel; Ellen M. Holfels; Nicolas P. Vogel; Kenneth M. Boyer; Marilyn B. Mets; Charles N. Swisher; Nancy J M Roizen; Laszlo K. Stein; Mark A. Stein; Joyce Hopkins; Shawn E. Withers; Douglas G. Mack; Rose A. Luciano; Paul Meier; Jack S. Remington; Rima L. McLeod

doi:10.1148/radiology.199.2.8668790

Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis

Dushyant V. Patel, Ellen M. Holfels, Nicolas P. Vogel, Kenneth M. Boyer, Marilyn B. Mets, Charles N. Swisher, Nancy J M Roizen, Laszlo K. Stein, Mark A. Stein, Joyce Hopkins, Shawn E. Withers, Douglas G. Mack, Rose A. Luciano, Paul Meier, Jack S. Remington, Rima L. McLeod^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.

Original language	English (US)
Pages (from-to)	433-440
Number of pages	8
Journal	Radiology
Volume	199
Issue number	2
DOIs	https://doi.org/10.1148/radiology.199.2.8668790
State	Published - May 1996

Keywords

Brain, calcification
Toxoplasmosis

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.199.2.8668790

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Patel, D. V., Holfels, E. M., Vogel, N. P., Boyer, K. M., Mets, M. B., Swisher, C. N., Roizen, N. J. M., Stein, L. K., Stein, M. A., Hopkins, J., Withers, S. E., Mack, D. G., Luciano, R. A., Meier, P., Remington, J. S., & McLeod, R. L. (1996). Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis. Radiology, 199(2), 433-440. https://doi.org/10.1148/radiology.199.2.8668790

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title = "Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis",

abstract = "PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.",

keywords = "Brain, calcification, Toxoplasmosis",

author = "Patel, {Dushyant V.} and Holfels, {Ellen M.} and Vogel, {Nicolas P.} and Boyer, {Kenneth M.} and Mets, {Marilyn B.} and Swisher, {Charles N.} and Roizen, {Nancy J M} and Stein, {Laszlo K.} and Stein, {Mark A.} and Joyce Hopkins and Withers, {Shawn E.} and Mack, {Douglas G.} and Luciano, {Rose A.} and Paul Meier and Remington, {Jack S.} and McLeod, {Rima L.}",

year = "1996",

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doi = "10.1148/radiology.199.2.8668790",

language = "English (US)",

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Patel, DV, Holfels, EM, Vogel, NP, Boyer, KM, Mets, MB, Swisher, CN, Roizen, NJM, Stein, LK, Stein, MA, Hopkins, J, Withers, SE, Mack, DG, Luciano, RA, Meier, P, Remington, JS & McLeod, RL 1996, 'Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis', Radiology, vol. 199, no. 2, pp. 433-440. https://doi.org/10.1148/radiology.199.2.8668790

TY - JOUR

T1 - Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis

AU - Patel, Dushyant V.

AU - Holfels, Ellen M.

AU - Vogel, Nicolas P.

AU - Boyer, Kenneth M.

AU - Mets, Marilyn B.

AU - Swisher, Charles N.

AU - Roizen, Nancy J M

AU - Stein, Laszlo K.

AU - Stein, Mark A.

AU - Hopkins, Joyce

AU - Withers, Shawn E.

AU - Mack, Douglas G.

AU - Luciano, Rose A.

AU - Meier, Paul

AU - Remington, Jack S.

AU - McLeod, Rima L.

PY - 1996/5

Y1 - 1996/5

N2 - PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.

AB - PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.

KW - Brain, calcification

KW - Toxoplasmosis

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JF - Radiology

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ER -

Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis

Abstract

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