Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis

Dushyant V. Patel, Ellen M. Holfels, Nicolas P. Vogel, Kenneth M. Boyer, Marilyn B. Mets, Charles N. Swisher, Nancy J M Roizen, Laszlo K. Stein, Mark A. Stein, Joyce Hopkins, Shawn E. Withers, Douglas G. Mack, Rose A. Luciano, Paul Meier, Jack S. Remington, Rima L. McLeod*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.

Original languageEnglish (US)
Pages (from-to)433-440
Number of pages8
Issue number2
StatePublished - May 1996


  • Brain, calcification
  • Toxoplasmosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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