Resolving inflammatory links between myocardial infarction and vascular dementia

Edward B. Thorp*, Margaret E. Flanagan, Brian Popko, Matthew DeBerge*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Myocardial infarction is associated with increased risk for vascular dementia. In both myocardial infarction and vascular dementia, there is evidence that elevated inflammatory biomarkers are associated with worsened clinical outcomes. Myocardial infarction leads to a systemic inflammatory response, which may contribute to recruitment or activation of myeloid cells, including monocytes, microglia, and perivascular macrophages, within the central nervous system. However, our understanding of the causative roles for these cells linking cardiac injury to the development and progression of dementia is incomplete. Herein, we provide an overview of inflammatory cellular and molecular links between myocardial infarction and vascular dementia and discuss strategies to resolve inflammation after myocardial infarction to limit neurovascular injury.

Original languageEnglish (US)
Article number101600
JournalSeminars in Immunology
StatePublished - Jan 2022


  • Myocardial infarction
  • Vascular dementia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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