Resonant cavity imaging biosensor

David A. Bergstein*, Michael F. Ruane, Bennett B. Goldberg, M. Selim Ünlü

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Resonant Cavity Imaging Biosensor (RCIB) detects binding between target biomolecules in solution and probe biomolecules fixed to a microarray surface. IR light couples resonantly through a 1 cm square cavity constructed from Si/SiO2 Bragg mirrors that contains the microarray surface. As the wavelength of the probe beam is swept, an IR camera monitors cavity transmittance at each pixel. The current setup detects 5 nm relief structures etched in the SiO2 surface of one of the Bragg mirrors. RCIB improves on existing label-free biosensing techniques by offering the combination of high sensitivity, high throughput, and real-time observation.

Original languageEnglish (US)
Title of host publication2004 1st IEEE Lightwave Technologies in Instrumentation and Measurement Conference
Pages101-105
Number of pages5
StatePublished - Dec 1 2004
Event2004 1st IEEE Lightwave Technologies in Instrumentation and Measurement Conference - Palisades, NY, United States
Duration: Oct 19 2004Oct 20 2004

Other

Other2004 1st IEEE Lightwave Technologies in Instrumentation and Measurement Conference
CountryUnited States
CityPalisades, NY
Period10/19/0410/20/04

Keywords

  • Biomedical imaging
  • Biomedical measurements
  • Biomedical transducer
  • Microarray

ASJC Scopus subject areas

  • Engineering(all)

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