G. S. Mitchell*, T. L. Baker-Herman, D. R. McCrimmon, J. L. Feldman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations


Respiratory control is accomplished by a complex, integrative control system with a difficult task to assure homeostasis of blood oxygen and carbon dioxide throughout life. Multiple neural mechanisms enable the respiratory control system to respond appropriately to changing environmental and physiological conditions, including feedback and feed-forward mechanisms that are modified by neuroplasticity. Ventilatory control disorders challenge homeostasis of respiratory gases, leading to severe morbidity and mortality. By greater understanding of mechanisms regulating blood gas homeostasis and pathological mechanisms of disease, new therapeutic approaches may be possible to treat devastating ventilatory control disorders with no known cures.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages10
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • BDNF
  • Carbon dioxide
  • Central chemoreceptors
  • Control of breathing
  • Exercise
  • Intermittent hypoxia
  • Long-term facilitation
  • Motoneuron
  • Motor neuron disease
  • Obstructive sleep apnea
  • Oxygen
  • Peripheral chemoreceptors
  • Plasticity
  • Serotonin
  • Sprinal injury

ASJC Scopus subject areas

  • Neuroscience(all)


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