Respiration

G. S. Mitchell; T. L. Baker-Herman; D. R. McCrimmon; J. L. Feldman

doi:10.1016/B978-008045046-9.00479-4

Respiration

G. S. Mitchell^*, T. L. Baker-Herman, D. R. McCrimmon, J. L. Feldman

^*Corresponding author for this work

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Scopus citations

Abstract

Respiratory control is accomplished by a complex, integrative control system with a difficult task to assure homeostasis of blood oxygen and carbon dioxide throughout life. Multiple neural mechanisms enable the respiratory control system to respond appropriately to changing environmental and physiological conditions, including feedback and feed-forward mechanisms that are modified by neuroplasticity. Ventilatory control disorders challenge homeostasis of respiratory gases, leading to severe morbidity and mortality. By greater understanding of mechanisms regulating blood gas homeostasis and pathological mechanisms of disease, new therapeutic approaches may be possible to treat devastating ventilatory control disorders with no known cures.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	121-130
Number of pages	10
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00479-4
State	Published - Jan 1 2009

Keywords

BDNF
Carbon dioxide
Central chemoreceptors
Control of breathing
Exercise
Intermittent hypoxia
Long-term facilitation
Motoneuron
Motor neuron disease
Obstructive sleep apnea
Oxygen
Peripheral chemoreceptors
Plasticity
Serotonin
Sprinal injury

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/B978-008045046-9.00479-4

Cite this

@inbook{ba3feee3be1543e0ba846347da33eb19,

title = "Respiration",

abstract = "Respiratory control is accomplished by a complex, integrative control system with a difficult task to assure homeostasis of blood oxygen and carbon dioxide throughout life. Multiple neural mechanisms enable the respiratory control system to respond appropriately to changing environmental and physiological conditions, including feedback and feed-forward mechanisms that are modified by neuroplasticity. Ventilatory control disorders challenge homeostasis of respiratory gases, leading to severe morbidity and mortality. By greater understanding of mechanisms regulating blood gas homeostasis and pathological mechanisms of disease, new therapeutic approaches may be possible to treat devastating ventilatory control disorders with no known cures.",

keywords = "BDNF, Carbon dioxide, Central chemoreceptors, Control of breathing, Exercise, Intermittent hypoxia, Long-term facilitation, Motoneuron, Motor neuron disease, Obstructive sleep apnea, Oxygen, Peripheral chemoreceptors, Plasticity, Serotonin, Sprinal injury",

author = "Mitchell, {G. S.} and Baker-Herman, {T. L.} and McCrimmon, {D. R.} and Feldman, {J. L.}",

year = "2009",

month = jan,

day = "1",

doi = "10.1016/B978-008045046-9.00479-4",

language = "English (US)",

isbn = "9780080450469",

pages = "121--130",

booktitle = "Encyclopedia of Neuroscience",

publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Respiration

AU - Mitchell, G. S.

AU - Baker-Herman, T. L.

AU - McCrimmon, D. R.

AU - Feldman, J. L.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Respiratory control is accomplished by a complex, integrative control system with a difficult task to assure homeostasis of blood oxygen and carbon dioxide throughout life. Multiple neural mechanisms enable the respiratory control system to respond appropriately to changing environmental and physiological conditions, including feedback and feed-forward mechanisms that are modified by neuroplasticity. Ventilatory control disorders challenge homeostasis of respiratory gases, leading to severe morbidity and mortality. By greater understanding of mechanisms regulating blood gas homeostasis and pathological mechanisms of disease, new therapeutic approaches may be possible to treat devastating ventilatory control disorders with no known cures.

AB - Respiratory control is accomplished by a complex, integrative control system with a difficult task to assure homeostasis of blood oxygen and carbon dioxide throughout life. Multiple neural mechanisms enable the respiratory control system to respond appropriately to changing environmental and physiological conditions, including feedback and feed-forward mechanisms that are modified by neuroplasticity. Ventilatory control disorders challenge homeostasis of respiratory gases, leading to severe morbidity and mortality. By greater understanding of mechanisms regulating blood gas homeostasis and pathological mechanisms of disease, new therapeutic approaches may be possible to treat devastating ventilatory control disorders with no known cures.

KW - BDNF

KW - Carbon dioxide

KW - Central chemoreceptors

KW - Control of breathing

KW - Exercise

KW - Intermittent hypoxia

KW - Long-term facilitation

KW - Motoneuron

KW - Motor neuron disease

KW - Obstructive sleep apnea

KW - Oxygen

KW - Peripheral chemoreceptors

KW - Plasticity

KW - Serotonin

KW - Sprinal injury

UR - http://www.scopus.com/inward/record.url?scp=84882875673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882875673&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00479-4

DO - 10.1016/B978-008045046-9.00479-4

M3 - Chapter

SN - 9780080450469

SP - 121

EP - 130

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Respiration

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this