Response property of inferior collicular neurons inherited from peripheral origin in mouse

Feixue Liang, Weiguo Yang, Xiaojun Zheng, Xiao Wang, Xiaodong Tan, Fan Zhang, Zhongju Xiao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The mechanisms underlying spike time coding in auditory system are not well understood. Despite of several models proposed to describe the first spike latency (FSL), there is no comparison of their respective performance. Here, based on FSL data from the central nucleus of inferior colliculus (CIC) in mouse to tone stimuli with varying rise function, rise time, and amplitude, we examined the previous models by comparing the recorded FSL with derived the FSL, respectively. We found that the LIEFTS (leaky integration, event formation, temporal summation) threshold model produced better match with the recorded data than other models. In addition, the model suggested that the short time constants derived from the FSL data (< 2 ms) cannot be attributed to IC neurons themselves (normally longer than 10 ms), but are similar to those for the inner hair cells (around 1.4 ms). Our results suggested that LIEFTS threshold model is a better fit for FSL, and FSL properties in central neurons can be inherited along the central auditory pathway, likely through faithful relays from the peripheral origins.

Original languageEnglish (US)
Pages (from-to)46-59
Number of pages14
JournalBrain research
Volume1369
DOIs
StatePublished - Oct 19 2011

Keywords

  • Auditory system
  • Firing threshold
  • First spike latency
  • Sound stimulus envelope

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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