Response to minoxidil in severe alopecia areata correlates with T lymphocyte stimulation

VIRGINIA C. FIEDLER‐WEISS*, CUNERA M. BUYS

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Mitogen‐induced T cell blastogenesis was determined in 47 patients with severe alopecia areata, before and after treatment with topical 5% minoxidil, and compared with control values. The group of 36 responders, who demonstrated terminal hair regrowth, showed significantly increased lymphocyte stimulation with concanavalin A and PHA before treatment, which decreased towards control values following hair regrowth. Lymphocytes from non‐responders showed no significant differences from controls either before or after treatment. The results suggest that enhanced T cell blastogenesis may predict the response of severe alopecia areata to topical 5% minoxidil therapy.

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalBritish Journal of Dermatology
Volume117
Issue number6
DOIs
StatePublished - Dec 1987
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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