Responsiveness of vitamin D-deficient fetal rat limb bones to parathyroid hormone in culture

P. H. Stern, B. P. Halloran, H. F. DeLuca, T. J. Hefley

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Radii and ulnae from 1-day fetal rats from normal or vitamin D-deficient mothers were treated with 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, or parathyroid hormone in vitro. Both sets of bones resorbed in response to all three agents. Statistical analysis indicated a purely additive model for the effects of vitamin D status and the bone-resorbing agents, with no evidence for interaction. The results suggest that the impaired calcemic response to parathyroid hormone seen in vitamin D-deficient animals in vivo is not the result of a specific unresponsiveness of vitamin D-deficient bone to parathyroid hormone.

Original languageEnglish (US)
Pages (from-to)E421-E424
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume7
Issue number4
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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