Resting State Cortical Connectivity Reflected in EEG Coherence in Individuals With Autism

Michael Andrew Murias; Sara J. Webb; Jessica Greenson; Geraldine Dawson

doi:10.1016/j.biopsych.2006.11.012

Resting State Cortical Connectivity Reflected in EEG Coherence in Individuals With Autism

Michael Andrew Murias^*, Sara J. Webb, Jessica Greenson, Geraldine Dawson

^*Corresponding author for this work

DevSci - Institute for Innovations in Developmental Sciences

Research output: Contribution to journal › Article › peer-review

419 Scopus citations

Abstract

Background: Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD. Methods: Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state. Results: In the θ (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower α range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz. Conclusions: Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.

Original language	English (US)
Pages (from-to)	270-273
Number of pages	4
Journal	Biological psychiatry
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2006.11.012
State	Published - Aug 1 2007

Funding

This project received generous support from the National Institute of Mental Health (U54MH066399), National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders (U19HD34565), and the Perry Research Fellowship Endowment.

Keywords

Developmental neuropathology
frontal lobe
functional connectivity
neural synchrony
oscillations

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/j.biopsych.2006.11.012

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title = "Resting State Cortical Connectivity Reflected in EEG Coherence in Individuals With Autism",

abstract = "Background: Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD. Methods: Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state. Results: In the θ (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower α range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz. Conclusions: Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.",

keywords = "Developmental neuropathology, frontal lobe, functional connectivity, neural synchrony, oscillations",

author = "Murias, {Michael Andrew} and Webb, {Sara J.} and Jessica Greenson and Geraldine Dawson",

note = "Funding Information: This project received generous support from the National Institute of Mental Health (U54MH066399), National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders (U19HD34565), and the Perry Research Fellowship Endowment. ",

year = "2007",

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doi = "10.1016/j.biopsych.2006.11.012",

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AU - Webb, Sara J.

AU - Greenson, Jessica

AU - Dawson, Geraldine

N1 - Funding Information: This project received generous support from the National Institute of Mental Health (U54MH066399), National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders (U19HD34565), and the Perry Research Fellowship Endowment.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Background: Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD. Methods: Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state. Results: In the θ (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower α range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz. Conclusions: Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.

AB - Background: Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD. Methods: Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state. Results: In the θ (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower α range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz. Conclusions: Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.

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KW - neural synchrony

KW - oscillations

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Resting State Cortical Connectivity Reflected in EEG Coherence in Individuals With Autism

Abstract

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Keywords

ASJC Scopus subject areas

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