Restoration of ethanol-compromised Th1 responses by sodium orthovanadate

Serge Ostrovidov*, Laurence M. Howard, Masato Ikeda, Akiko Ikeda, Carl Waltenbaugh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Alcohol consumption often diminishes antigen-specific cell-mediated immunity. In alcohol-consuming mice IFN-γ and delayed-type hypersensitivity (DTH) responses are blunted, although antigen-specific T cell proliferation and IL-2 responses are largely unaffected, suggesting that alcohol differentially affects signal transduction pathways. In the present report we explore the use of the phosphatase inhibitor, Na3VO4 to restore IFN-γ secretion in the presence of ethanol both in vivo and in vitro. We show that Na3VO4 restores IFN-γ in vitro and antigen-specific DTH in vivo to the levels seen in alcohol non-consuming mice. Our data support the contention that ethanol, by up-regulating phosphotyrosine phosphatase, diminishes the IFN-γ signal transduction pathway.

Original languageEnglish (US)
Pages (from-to)1239-1245
Number of pages7
JournalInternational Immunology
Issue number11
StatePublished - Nov 1 2002


  • Alcohol
  • IFN-γ
  • Mouse
  • NaVO
  • Protein tyrosine phosphatase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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