Restoring sensorimotor function through intracortical interfaces: Progress and looming challenges

Sliman J. Bensmaia, Lee E. Miller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

236 Scopus citations


The loss of a limb or paralysis resulting from spinal cord injury has devastating consequences on quality of life. One approach to restoring lost sensory and motor abilities in amputees and patients with tetraplegia is to supply them with implants that provide a direct interface with the CNS. Such brain-machine interfaces might enable a patient to exert voluntary control over a prosthetic or robotic limb or over the electrically induced contractions of paralysed muscles. A parallel interface could convey sensory information about the consequences of these movements back to the patient. Recent developments in the algorithms that decode motor intention from neuronal activity and in approaches to convey sensory feedback by electrically stimulating neurons, using biomimetic and adaptation-based approaches, have shown the promise of invasive interfaces with sensorimotor cortices, although substantial challenges remain.

Original languageEnglish (US)
Pages (from-to)313-325
Number of pages13
JournalNature Reviews Neuroscience
Issue number5
StatePublished - May 2014

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Restoring sensorimotor function through intracortical interfaces: Progress and looming challenges'. Together they form a unique fingerprint.

Cite this