Restricted food intake limits brown adipose tissue hypertrophy in cold exposure

T. Scott Johnson; Shawne Murray; James B. Young; Lewis Landsberg

doi:10.1016/0024-3205(82)90555-0

Restricted food intake limits brown adipose tissue hypertrophy in cold exposure

T. Scott Johnson^*, Shawne Murray, James B. Young, Lewis Landsberg

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Two factors that may determine brown adipose tissue (BAT) hypertrophy during conditions of increased metabolic heat production are increased food intake and increased sympathetic nervous system (SNS) activity. Since these two proceed pari passu during cold exposure, their independent contributions to BAT hypertrophy are unknown. To examine the role of each, we limited the food intake of a group of a cold exposed rats by pair feeding them to warm exposed control rats and then compared the pair fed rats to ad lib fed cold exposed animals. Restricted food intake limited absolute BAT hypertrophy (0.226±0.01 g. vs 0.488±0.02 g, pair fed vs ad lib, P<0.01), BAT as per cent body weight (0.189±0.12 vs 0.252±0.012, P<0.01) and BAT protein content (34.4±3.8 vs 48.9±2.6 mg, P<0.01) despite evidence of quantitatively similar activation of the SNS in BAT in both groups. We conclude that increased food intake contributes to BAT hypertrophy in cold exposure independent of sympathetic activity.

Original language	English (US)
Pages (from-to)	1423-1426
Number of pages	4
Journal	Life Sciences
Volume	30
Issue number	17
DOIs	https://doi.org/10.1016/0024-3205(82)90555-0
State	Published - Apr 26 1982

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Restricted food intake limits brown adipose tissue hypertrophy in cold exposure",

abstract = "Two factors that may determine brown adipose tissue (BAT) hypertrophy during conditions of increased metabolic heat production are increased food intake and increased sympathetic nervous system (SNS) activity. Since these two proceed pari passu during cold exposure, their independent contributions to BAT hypertrophy are unknown. To examine the role of each, we limited the food intake of a group of a cold exposed rats by pair feeding them to warm exposed control rats and then compared the pair fed rats to ad lib fed cold exposed animals. Restricted food intake limited absolute BAT hypertrophy (0.226±0.01 g. vs 0.488±0.02 g, pair fed vs ad lib, P<0.01), BAT as per cent body weight (0.189±0.12 vs 0.252±0.012, P<0.01) and BAT protein content (34.4±3.8 vs 48.9±2.6 mg, P<0.01) despite evidence of quantitatively similar activation of the SNS in BAT in both groups. We conclude that increased food intake contributes to BAT hypertrophy in cold exposure independent of sympathetic activity.",

author = "{Scott Johnson}, T. and Shawne Murray and Young, {James B.} and Lewis Landsberg",

note = "Funding Information: T. Scott Johnson is recipient of NHLBI Clinical Investigator Award HL00896. This article was supported in part by USPHS grants AM20378, AM26455 and HL24084. The secretarial assistance of Georgette Briguglio is gratefully acknowledged.",

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AU - Murray, Shawne

AU - Young, James B.

AU - Landsberg, Lewis

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PY - 1982/4/26

Y1 - 1982/4/26

N2 - Two factors that may determine brown adipose tissue (BAT) hypertrophy during conditions of increased metabolic heat production are increased food intake and increased sympathetic nervous system (SNS) activity. Since these two proceed pari passu during cold exposure, their independent contributions to BAT hypertrophy are unknown. To examine the role of each, we limited the food intake of a group of a cold exposed rats by pair feeding them to warm exposed control rats and then compared the pair fed rats to ad lib fed cold exposed animals. Restricted food intake limited absolute BAT hypertrophy (0.226±0.01 g. vs 0.488±0.02 g, pair fed vs ad lib, P<0.01), BAT as per cent body weight (0.189±0.12 vs 0.252±0.012, P<0.01) and BAT protein content (34.4±3.8 vs 48.9±2.6 mg, P<0.01) despite evidence of quantitatively similar activation of the SNS in BAT in both groups. We conclude that increased food intake contributes to BAT hypertrophy in cold exposure independent of sympathetic activity.

AB - Two factors that may determine brown adipose tissue (BAT) hypertrophy during conditions of increased metabolic heat production are increased food intake and increased sympathetic nervous system (SNS) activity. Since these two proceed pari passu during cold exposure, their independent contributions to BAT hypertrophy are unknown. To examine the role of each, we limited the food intake of a group of a cold exposed rats by pair feeding them to warm exposed control rats and then compared the pair fed rats to ad lib fed cold exposed animals. Restricted food intake limited absolute BAT hypertrophy (0.226±0.01 g. vs 0.488±0.02 g, pair fed vs ad lib, P<0.01), BAT as per cent body weight (0.189±0.12 vs 0.252±0.012, P<0.01) and BAT protein content (34.4±3.8 vs 48.9±2.6 mg, P<0.01) despite evidence of quantitatively similar activation of the SNS in BAT in both groups. We conclude that increased food intake contributes to BAT hypertrophy in cold exposure independent of sympathetic activity.

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Restricted food intake limits brown adipose tissue hypertrophy in cold exposure

Abstract

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