Restriction fragment length polymorphisms of the insulin gene hypervariable region in gestational onset diabetes mellitus

Carole Ober*, Candace J. Wason, Kelly Andrew, Sharon Dooley

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Restriction fragment length polymorphisms in the insulin gene hypervariable region are compared among 93 women with gestational onset diabetes mellitus and 146 women with normal glucose tolerance during pregnancy. No significant differences in gene or genotype frequencies were observed in the overall sample (p > 0.50). However, an increased frequency of one allele (class 1) was observed among nonoverweight patients with gestational onset diabetes mellitus with elevated fasting plasma glucose levels compared with age-, race-, and parity-matched control subjects (p = 0.061). These data suggest that gestational onset diabetes mellitus is a heterogeneous disorder with respect to both genotypic and phenotypic characteristics, and that restriction fragment length polymorphisms near the insulin gene may serve as a molecular marker for susceptibility to gestational onset diabetes mellitus only in some women.

Original languageEnglish (US)
Pages (from-to)1364-1368
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume157
Issue number6
DOIs
StatePublished - 1987

Keywords

  • Gestational diabetes
  • genetic heterogeneity
  • insulin gene
  • restriction fragment length polymorphism analysis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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