TY - JOUR
T1 - Restriction fragment length polymorphisms of the insulin gene hypervariable region in gestational onset diabetes mellitus
AU - Ober, Carole
AU - Wason, Candace J.
AU - Andrew, Kelly
AU - Dooley, Sharon
PY - 1987
Y1 - 1987
N2 - Restriction fragment length polymorphisms in the insulin gene hypervariable region are compared among 93 women with gestational onset diabetes mellitus and 146 women with normal glucose tolerance during pregnancy. No significant differences in gene or genotype frequencies were observed in the overall sample (p > 0.50). However, an increased frequency of one allele (class 1) was observed among nonoverweight patients with gestational onset diabetes mellitus with elevated fasting plasma glucose levels compared with age-, race-, and parity-matched control subjects (p = 0.061). These data suggest that gestational onset diabetes mellitus is a heterogeneous disorder with respect to both genotypic and phenotypic characteristics, and that restriction fragment length polymorphisms near the insulin gene may serve as a molecular marker for susceptibility to gestational onset diabetes mellitus only in some women.
AB - Restriction fragment length polymorphisms in the insulin gene hypervariable region are compared among 93 women with gestational onset diabetes mellitus and 146 women with normal glucose tolerance during pregnancy. No significant differences in gene or genotype frequencies were observed in the overall sample (p > 0.50). However, an increased frequency of one allele (class 1) was observed among nonoverweight patients with gestational onset diabetes mellitus with elevated fasting plasma glucose levels compared with age-, race-, and parity-matched control subjects (p = 0.061). These data suggest that gestational onset diabetes mellitus is a heterogeneous disorder with respect to both genotypic and phenotypic characteristics, and that restriction fragment length polymorphisms near the insulin gene may serve as a molecular marker for susceptibility to gestational onset diabetes mellitus only in some women.
KW - Gestational diabetes
KW - genetic heterogeneity
KW - insulin gene
KW - restriction fragment length polymorphism analysis
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U2 - 10.1016/S0002-9378(87)80225-9
DO - 10.1016/S0002-9378(87)80225-9
M3 - Article
C2 - 2892412
AN - SCOPUS:0023545219
VL - 157
SP - 1364
EP - 1368
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6
ER -