Results of radiation therapy in early glottic carcinoma: Multivariate analysis of prognostic and radiation therapy variables

William Small, Bharat B. Mittal*, William N. Brand, R. M. Shetty, Alfred W. Rademaker, Gerald G. Beck, Stanley V. Hoover

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A detailed retrospective analysis was performed with 103 patients who had T1 carcinoma of the glottic larynx and underwent radiation therapy between 1960 and 1987. Prognostic and radiation therapy variables were analyzed including sex; age; staging procedures; mucosal extent; histologic grading of tumor; field size; use of wedges; treatment of alternate fields versus both fields every day; nominal standard dose; time, dose, and fraction; dose per fraction; total radiation dose per fraction; total radiation doses; and the impact of cord stripping. Initial local control was 89%, and ultimate control after surgical salvage was 97%, with a 5- and 10-year adjusted survival of 98%. Univariate analysis indicated that larger field size (P = .04), histologic grade (P = .02), and treatment strategy (P = .08) were of some value in predicting recurrence. Multivariate analysis indicated that field size (P = .03) was the only significant variable in predicting local recurrence. These data confirm that radiation is highly effective in the treatment of early laryngeal cancer.

Original languageEnglish (US)
Pages (from-to)789-794
Number of pages6
JournalRadiology
Volume183
Issue number3
DOIs
StatePublished - Jun 1992

Keywords

  • Larynx, neoplasms, 271.37
  • Larynx, therapeutic radiology, 271.1299
  • Vocal cords, neoplasms, 2714.37
  • Vocal cords, therapeutic radiology, 2714.1299

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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