TY - JOUR
T1 - Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1
AU - Zou, Ting
AU - Yang, Yi
AU - Xia, Fei
AU - Huang, Anfei
AU - Gao, Xiaoming
AU - Fang, Deyu
AU - Xiong, Sidong
AU - Zhang, Jinping
PY - 2013/9/20
Y1 - 2013/9/20
N2 - Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibits the activation and cytokine production of T cells in vitro and in vivo. Sirt1 expression was up-regulated in resveratrol-treated T cells. Once Sirt1 was down-regulated in the T cells, the resveratrol-induced inhibition of T cell activation noticeably diminished. The acetylation of c-Jun decreased and its translocation was impeded in the resveratrol-treated T cells. The incidence and severity of collagen-induced arthritis in the resveratrol-treated mice were considerably reduced.
AB - Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibits the activation and cytokine production of T cells in vitro and in vivo. Sirt1 expression was up-regulated in resveratrol-treated T cells. Once Sirt1 was down-regulated in the T cells, the resveratrol-induced inhibition of T cell activation noticeably diminished. The acetylation of c-Jun decreased and its translocation was impeded in the resveratrol-treated T cells. The incidence and severity of collagen-induced arthritis in the resveratrol-treated mice were considerably reduced.
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U2 - 10.1371/journal.pone.0075139
DO - 10.1371/journal.pone.0075139
M3 - Article
C2 - 24073240
AN - SCOPUS:84884489459
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 9
M1 - e75139
ER -