Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist

Olivier Van Reeth*, Elizabeth Olivares, Fred William Turek, Laurent Granjon, Elizabeth Mocaer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

USING 'jet lag' paradigms involving phase shifts in the light-dark (LD) cycle, we studied the effects of S-20098 on the circadian clock of a diurnal rodent. Arvicanthis mordax, entrained to a regular LD cycle, were subjected to advance shifts (i.e. 4, 6 or 8 h) in the LD cycle and injected with vehicle or the melatonin agonist S-20098 (20 mg/kg) the day of the shift (and also on subsequent days in the 6 h or 8 h shift paradigms). In each condition, S-20098 accelerated by about 30% resynchronization to the new LD cycle. These data, which are the first to demonstrate the chronobiotic effects of a melatonin agonist in a diurnal rodent, provide new insights for the design of human chronopharmacological protocols.

Original languageEnglish (US)
Pages (from-to)1901-1905
Number of pages5
JournalNeuroreport
Volume9
Issue number8
DOIs
StatePublished - Jun 1 1998

Keywords

  • Arvicanthis
  • Circadian clock phase shift
  • Diurnal rodent
  • Jet lag
  • Melatonin agonist

ASJC Scopus subject areas

  • Neuroscience(all)

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