Retapamulin Activity Against Pediatric Strains of Mupirocin-resistant Methicillin-resistant Staphylococcus aureus

Ami B. Patel, Jennifer Lighter, Yi Fulmer, Richard Copin, Adam J. Ratner, Bo Shopsin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Retapamulin activity against 53 isolates obtained from a mupirocin-resistant community-acquired methicillin-resistant Staphylococcus aureus pediatric disease cluster was evaluated using broth microdilution. All strains were susceptible to retapamulin with minimum inhibitory concentrations ≤ 0.5 μg/mL. DNA sequence analysis of rplC and cfr identified one rplC strain variant that did not demonstrate reduced phenotypic susceptibility to retapamulin. These results demonstrate that retapamulin may be a useful alternative therapy for mupirocin-resistant community-acquired methicillin-resistant S. aureus, especially in disease clusters.

Original languageEnglish (US)
Pages (from-to)637-638
Number of pages2
JournalThe Pediatric infectious disease journal
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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