Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid

Daniel M. Rosenbaum*, Pearl S. Rosenbaum, Anita Gupta, Mark D. Michaelson, David H. Hall, John A. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult. Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process.

Original languageEnglish (US)
Pages (from-to)3445-3451
Number of pages7
JournalVision Research
Issue number24
StatePublished - Dec 1997


  • Apoptosis
  • Aurintricarboxylic acid
  • Ischemia
  • Retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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