Retinal oxygen extraction in humans

René M. Werkmeister, Doreen Schmidl, Gerold Aschinger, Veronika Doblhoff-Dier, Stefan Palkovits, Magdalena Wirth, Gerhard Garhöfer, Robert A. Linsenmeier, Rainer A. Leitgeb, Leopold Schmetterer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

Original languageEnglish (US)
Article number15763
JournalScientific reports
Volume5
DOIs
StatePublished - Oct 27 2015

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Retinal oxygen extraction in humans'. Together they form a unique fingerprint.

Cite this