Retinal oxygen extraction in humans

René M. Werkmeister; Doreen Schmidl; Gerold Aschinger; Veronika Doblhoff-Dier; Stefan Palkovits; Magdalena Wirth; Gerhard Garhöfer; Robert A. Linsenmeier; Rainer A. Leitgeb; Leopold Schmetterer

doi:10.1038/srep15763

Retinal oxygen extraction in humans

René M. Werkmeister, Doreen Schmidl, Gerold Aschinger, Veronika Doblhoff-Dier, Stefan Palkovits, Magdalena Wirth, Gerhard Garhöfer, Robert A. Linsenmeier, Rainer A. Leitgeb, Leopold Schmetterer^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

Original language	English (US)
Article number	15763
Journal	Scientific reports
Volume	5
DOIs	https://doi.org/10.1038/srep15763
State	Published - Oct 27 2015

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@article{8a22b3999f9a491c9158a91ce6eb544d,

title = "Retinal oxygen extraction in humans",

abstract = "Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.",

author = "Werkmeister, {Ren{\'e} M.} and Doreen Schmidl and Gerold Aschinger and Veronika Doblhoff-Dier and Stefan Palkovits and Magdalena Wirth and Gerhard Garh{\"o}fer and Linsenmeier, {Robert A.} and Leitgeb, {Rainer A.} and Leopold Schmetterer",

note = "Funding Information: Financial support from the Austrian Science Foundation (FWF, project P26157) is acknowledged.",

year = "2015",

month = oct,

day = "27",

doi = "10.1038/srep15763",

language = "English (US)",

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journal = "Scientific Reports",

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AU - Werkmeister, René M.

AU - Schmidl, Doreen

AU - Aschinger, Gerold

AU - Doblhoff-Dier, Veronika

AU - Palkovits, Stefan

AU - Wirth, Magdalena

AU - Garhöfer, Gerhard

AU - Linsenmeier, Robert A.

AU - Leitgeb, Rainer A.

AU - Schmetterer, Leopold

N1 - Funding Information: Financial support from the Austrian Science Foundation (FWF, project P26157) is acknowledged.

PY - 2015/10/27

Y1 - 2015/10/27

N2 - Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

AB - Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

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Retinal oxygen extraction in humans

Abstract

ASJC Scopus subject areas

UN SDGs

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