Retinal Periphlebitis in Patients with Acquired Immunodeficiency Syndrome with Cytomegalovirus Retinitis Mimics Acute Frosted Retinal Periphlebitis

Maurice F. Rabb, Lee M. Jampol*, Richard H. Fish, Randy V. Campo, Warren M. Sobol, Norbert M. Becker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Acute frosted retinal periphlebitis is an inflammatory condition of unknown origin characterized by marked perivenular infiltration in otherwise healthy patients. We encountered seven patients with acquired immunodeficiency syndrome who exhibited visual loss associated with an unusual diffuse retinal periphlebitis very similar in appearance to acute frosted retinal periphlebitis. Each patient developed a thick inflammatory infiltrate surrounding the retinal venules, creating a frosted appearance. Two cases were bilateral. All patients had areas of more typical cytomegalovirus retinitis in their involved eye(s). Five of six patients treated with ganciclovir sodium showed improvement not only of the cytomegalovirus retinitis but also of the periphlebitis. Although we do not have histopathologic evidence that cytomegalovirus was the cause of these cases of periphlebitis, we believe that periphlebitis may be a previously unrecognized finding of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. So far, there is no evidence implicating cytomegalovirus as the cause of acute frosted retinal periphlebitis in healthy patients.

Original languageEnglish (US)
Pages (from-to)1257-1260
Number of pages4
JournalArchives of ophthalmology
Volume110
Issue number9
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Ophthalmology

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