Retinoid metabolism in endometriosis

Yiğit Çakıroğlu, Rafael Confino, MaryEllen Pavone*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Endometriosis is an estrogen-dependent disease in which progesterone resistance and inflammation have been found to be major mechanisms responsible for its development and progression. When compared to eutopic endometrium, key molecules have been found to be differentially expressed, which contribute to these mechanisms. One pathway that is aberrant in endometriotic tissue when compared to eutopic endometrium is the retinoic acid signaling pathway. This review focuses on the role of the retinoid signaling pathway in endometriosis and summarizes evidence that supports the use of retinoid compounds for the stimulation of pro-apoptotic activity in these cells.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalJournal of Endometriosis and Pelvic Pain Disorders
Volume9
Issue number4
DOIs
StatePublished - Oct 1 2017

Keywords

  • Apoptosis
  • Endometriosis
  • Endometrium
  • Retinoid metabolism
  • Retinoid signaling

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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