Abstract
Endometriosis is an estrogen-dependent disease in which progesterone resistance and inflammation have been found to be major mechanisms responsible for its development and progression. When compared to eutopic endometrium, key molecules have been found to be differentially expressed, which contribute to these mechanisms. One pathway that is aberrant in endometriotic tissue when compared to eutopic endometrium is the retinoic acid signaling pathway. This review focuses on the role of the retinoid signaling pathway in endometriosis and summarizes evidence that supports the use of retinoid compounds for the stimulation of pro-apoptotic activity in these cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 232-238 |
| Number of pages | 7 |
| Journal | Journal of Endometriosis and Pelvic Pain Disorders |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1 2017 |
Keywords
- Apoptosis
- Endometriosis
- Endometrium
- Retinoid metabolism
- Retinoid signaling
ASJC Scopus subject areas
- Obstetrics and Gynecology