Abstract
Background: To evaluate the measurement properties (e.g. content validity, reliability and ability to detect change) of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). Methods: One-on-one semi-structured qualitative interviews with adult patients with active PsA evaluated the content validity of FACIT-Fatigue. Quantitative measurement properties were evaluated using data from phase III tofacitinib randomized controlled trials (RCTs) in PsA: OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439). Results: Of 12 patients included in the qualitative study, 2 (17%) had mild, 8 (67%) had moderate, and 2 (17%) had severe PsA disease activity; 7 (58%) attributed fatigue to PsA, and 7 (58%) rated fatigue as important or extremely important. Most patients considered the FACIT-Fatigue items relevant to their PsA experience and understood item content and response options as intended. In the psychometric analysis of RCT data, a second-order confirmatory factor model fit the data well (Bentler’s Comparative Fit Index ≥0.92). FACIT-Fatigue demonstrated good internal consistency (Cronbach’s coefficient α ≥ 0.90), test-retest reliability (Intraclass Correlation Coefficient ≥ 0.80) and a strong correlation with SF-36 Vitality (r > 0.80). A robust relationship between disease activity (based on Patient’s Global Assessment of Psoriasis and Arthritis) and FACIT-Fatigue was observed (effect sizes > 1.4), with clinically important difference for the FACIT-Fatigue total score estimated as 3.1 points, and the responder definition estimated as a 4-point improvement for FACIT-Fatigue total score. Conclusion: Fatigue was confirmed to be an important symptom to patients with PsA, and FACIT-Fatigue was found to be a reliable and valid measure in this population.
Original language | English (US) |
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Article number | 5 |
Journal | Journal of patient-reported outcomes |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1 2019 |
Keywords
- Content validity
- FACIT-fatigue
- Psoriatic arthritis
- Psychometric properties
- Tofacitinib
ASJC Scopus subject areas
- Health Informatics
- Health Information Management
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Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis
Cella, D. (Creator), Wilson, H. (Creator), Shalhoub, H. (Creator), Revicki, D. A. (Creator), Cappelleri, J. C. (Creator), Bushmakin, A. G. (Creator), Kudlacz, E. (Creator) & Hsu, M. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.c.4378046.v1, https://springernature.figshare.com/collections/Content_validity_and_psychometric_evaluation_of_Functional_Assessment_of_Chronic_Illness_Therapy-Fatigue_in_patients_with_psoriatic_arthritis/4378046/1
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