Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4)

Alexandra Garancher; Hiromichi Suzuki; Svasti Haricharan; Lianne Q. Chau; Meher Beigi Masihi; Jessica M. Rusert; Paula S. Norris; Florent Carrette; Megan M. Romero; Sorana A. Morrissy; Patryk Skowron; Florence M.G. Cavalli; Hamza Farooq; Vijay Ramaswamy; Steven J.M. Jones; Richard A. Moore; Andrew J. Mungall; Yussanne Ma; Nina Thiessen; Yisu Li; Alaide Morcavallo; Lin Qi; Mari Kogiso; Yuchen Du; Patricia Baxter; Jacob J. Henderson; John R. Crawford; Michael L. Levy; James M. Olson; Yoon Jae Cho; Aniruddha J. Deshpande; Xiao Nan Li; Louis Chesler; Marco A. Marra; Harald Wajant; Oren J. Becher; Linda M. Bradley; Carl F. Ware; Michael D. Taylor; Robert J. Wechsler-Reya

doi:10.1038/s41593-021-00994-3

Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4)

Alexandra Garancher, Hiromichi Suzuki, Svasti Haricharan, Lianne Q. Chau, Meher Beigi Masihi, Jessica M. Rusert, Paula S. Norris, Florent Carrette, Megan M. Romero, Sorana A. Morrissy, Patryk Skowron, Florence M.G. Cavalli, Hamza Farooq, Vijay Ramaswamy, Steven J.M. Jones, Richard A. Moore, Andrew J. Mungall, Yussanne Ma, Nina Thiessen, Yisu LiAlaide Morcavallo, Lin Qi, Mari Kogiso, Yuchen Du, Patricia Baxter, Jacob J. Henderson, John R. Crawford, Michael L. Levy, James M. Olson, Yoon Jae Cho, Aniruddha J. Deshpande, Xiao Nan Li, Louis Chesler, Marco A. Marra, Harald Wajant, Oren J. Becher, Linda M. Bradley, Carl F. Ware, Michael D. Taylor, Robert J. Wechsler-Reya^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The authors are retracting this paper owing to issues with the integrity of the data presented. Specifically, inconsistencies in the flow cytometry data in Figs. 2d, 4b, 5c,d, 5g,h, 6a,b and 7a-d, and Extended Data Figs. 2b, 3a-i, and 6c-j were found, with selected experimental samples collected using different settings from their corresponding controls. Thus, the data in these figures do not reflect the true fluorescence of the samples in question. In addition, we have been unable to replicate the key in vivo findings in the paper, including those presented in Fig. 7e-h and Extended Data Fig. 8d-k. These concerns undermine our confidence in the study and we therefore wish to retract the article in its entirety. We deeply regret this incident and apologize to the scientific community.

Original language	English (US)
Pages (from-to)	127
Number of pages	1
Journal	Nature neuroscience
Volume	25
Issue number	1
DOIs	https://doi.org/10.1038/s41593-021-00994-3
State	Published - Jan 2022

ASJC Scopus subject areas

General Neuroscience

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Garancher, A., Suzuki, H., Haricharan, S., Chau, L. Q., Masihi, M. B., Rusert, J. M., Norris, P. S., Carrette, F., Romero, M. M., Morrissy, S. A., Skowron, P., Cavalli, F. M. G., Farooq, H., Ramaswamy, V., Jones, S. J. M., Moore, R. A., Mungall, A. J., Ma, Y., Thiessen, N., ... Wechsler-Reya, R. J. (2022). Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4). Nature neuroscience, 25(1), 127. https://doi.org/10.1038/s41593-021-00994-3

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title = "Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4)",

abstract = "The authors are retracting this paper owing to issues with the integrity of the data presented. Specifically, inconsistencies in the flow cytometry data in Figs. 2d, 4b, 5c,d, 5g,h, 6a,b and 7a-d, and Extended Data Figs. 2b, 3a-i, and 6c-j were found, with selected experimental samples collected using different settings from their corresponding controls. Thus, the data in these figures do not reflect the true fluorescence of the samples in question. In addition, we have been unable to replicate the key in vivo findings in the paper, including those presented in Fig. 7e-h and Extended Data Fig. 8d-k. These concerns undermine our confidence in the study and we therefore wish to retract the article in its entirety. We deeply regret this incident and apologize to the scientific community.",

author = "Alexandra Garancher and Hiromichi Suzuki and Svasti Haricharan and Chau, {Lianne Q.} and Masihi, {Meher Beigi} and Rusert, {Jessica M.} and Norris, {Paula S.} and Florent Carrette and Romero, {Megan M.} and Morrissy, {Sorana A.} and Patryk Skowron and Cavalli, {Florence M.G.} and Hamza Farooq and Vijay Ramaswamy and Jones, {Steven J.M.} and Moore, {Richard A.} and Mungall, {Andrew J.} and Yussanne Ma and Nina Thiessen and Yisu Li and Alaide Morcavallo and Lin Qi and Mari Kogiso and Yuchen Du and Patricia Baxter and Henderson, {Jacob J.} and Crawford, {John R.} and Levy, {Michael L.} and Olson, {James M.} and Cho, {Yoon Jae} and Deshpande, {Aniruddha J.} and Li, {Xiao Nan} and Louis Chesler and Marra, {Marco A.} and Harald Wajant and Becher, {Oren J.} and Bradley, {Linda M.} and Ware, {Carl F.} and Taylor, {Michael D.} and Wechsler-Reya, {Robert J.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.",

year = "2022",

month = jan,

doi = "10.1038/s41593-021-00994-3",

language = "English (US)",

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Garancher, A, Suzuki, H, Haricharan, S, Chau, LQ, Masihi, MB, Rusert, JM, Norris, PS, Carrette, F, Romero, MM, Morrissy, SA, Skowron, P, Cavalli, FMG, Farooq, H, Ramaswamy, V, Jones, SJM, Moore, RA, Mungall, AJ, Ma, Y, Thiessen, N, Li, Y, Morcavallo, A, Qi, L, Kogiso, M, Du, Y, Baxter, P, Henderson, JJ, Crawford, JR, Levy, ML, Olson, JM, Cho, YJ, Deshpande, AJ, Li, XN, Chesler, L, Marra, MA, Wajant, H, Becher, OJ, Bradley, LM, Ware, CF, Taylor, MD & Wechsler-Reya, RJ 2022, 'Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4)', Nature neuroscience, vol. 25, no. 1, pp. 127. https://doi.org/10.1038/s41593-021-00994-3

TY - JOUR

T1 - Retraction Note

T2 - Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4)

AU - Garancher, Alexandra

AU - Suzuki, Hiromichi

AU - Haricharan, Svasti

AU - Chau, Lianne Q.

AU - Masihi, Meher Beigi

AU - Rusert, Jessica M.

AU - Norris, Paula S.

AU - Carrette, Florent

AU - Romero, Megan M.

AU - Morrissy, Sorana A.

AU - Skowron, Patryk

AU - Cavalli, Florence M.G.

AU - Farooq, Hamza

AU - Ramaswamy, Vijay

AU - Jones, Steven J.M.

AU - Moore, Richard A.

AU - Mungall, Andrew J.

AU - Ma, Yussanne

AU - Thiessen, Nina

AU - Li, Yisu

AU - Morcavallo, Alaide

AU - Qi, Lin

AU - Kogiso, Mari

AU - Du, Yuchen

AU - Baxter, Patricia

AU - Henderson, Jacob J.

AU - Crawford, John R.

AU - Levy, Michael L.

AU - Olson, James M.

AU - Cho, Yoon Jae

AU - Deshpande, Aniruddha J.

AU - Li, Xiao Nan

AU - Chesler, Louis

AU - Marra, Marco A.

AU - Wajant, Harald

AU - Becher, Oren J.

AU - Bradley, Linda M.

AU - Ware, Carl F.

AU - Taylor, Michael D.

AU - Wechsler-Reya, Robert J.

PY - 2022/1

Y1 - 2022/1

N2 - The authors are retracting this paper owing to issues with the integrity of the data presented. Specifically, inconsistencies in the flow cytometry data in Figs. 2d, 4b, 5c,d, 5g,h, 6a,b and 7a-d, and Extended Data Figs. 2b, 3a-i, and 6c-j were found, with selected experimental samples collected using different settings from their corresponding controls. Thus, the data in these figures do not reflect the true fluorescence of the samples in question. In addition, we have been unable to replicate the key in vivo findings in the paper, including those presented in Fig. 7e-h and Extended Data Fig. 8d-k. These concerns undermine our confidence in the study and we therefore wish to retract the article in its entirety. We deeply regret this incident and apologize to the scientific community.

AB - The authors are retracting this paper owing to issues with the integrity of the data presented. Specifically, inconsistencies in the flow cytometry data in Figs. 2d, 4b, 5c,d, 5g,h, 6a,b and 7a-d, and Extended Data Figs. 2b, 3a-i, and 6c-j were found, with selected experimental samples collected using different settings from their corresponding controls. Thus, the data in these figures do not reflect the true fluorescence of the samples in question. In addition, we have been unable to replicate the key in vivo findings in the paper, including those presented in Fig. 7e-h and Extended Data Fig. 8d-k. These concerns undermine our confidence in the study and we therefore wish to retract the article in its entirety. We deeply regret this incident and apologize to the scientific community.

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DO - 10.1038/s41593-021-00994-3

M3 - Comment/debate

C2 - 34907396

AN - SCOPUS:85121354130

SN - 1097-6256

VL - 25

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JO - Nature neuroscience

JF - Nature neuroscience

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Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (Nature Neuroscience, (2020), 10.1038/s41593-020-0628-4)

Abstract

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