Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets

Jonathan A. Stefely; Michael Gailey; Michael Knudson; Larry J. Dumont; Thomas J. Raife; Noelle I. Samia

doi:10.1111/trf.15865

Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets

Jonathan A. Stefely, Michael Gailey, Michael Knudson, Larry J. Dumont, Thomas J. Raife^*, Noelle I. Samia^*

^*Corresponding author for this work

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Abstract

BACKGROUND: The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient-dependent factors are well described, donor-dependent variables remain poorly understood. STUDY DESIGN AND METHODS: To explore donor-dependent variables we conducted 2 retrospective studies of platelet transfusion outcomes in repeat donors. One study analyzed multiple autologous, radiolabeled platelet transfusions, and a second study analyzed multiple clinical platelet transfusions from a small cohort of repeat donors. RESULTS: In 36 subjects, multiple within-subject determinations of recovery and survival of radiolabeled autologous platelets revealed a relative consistency in platelet recoveries within donors compared to the range of recoveries among donors. Intraclass correlation coefficients for platelet recovery were 43% to 93%. In 524 ABO-compatible clinical platelet transfusions derived from seven donors, a linear mixed-effects model revealed significant donor-dependent differences in corrected count increments for units stored for 4 or 5 days. CONCLUSIONS: These two studies indicate reproducible donor-dependent differences in transfused platelet recovery, suggesting a possible heritable influence on the quality of transfused platelets.

Original language	English (US)
Pages (from-to)	1837-1845
Number of pages	9
Journal	Transfusion
Volume	60
Issue number	8
DOIs	https://doi.org/10.1111/trf.15865
State	Published - Aug 1 2020

ASJC Scopus subject areas

Hematology
Immunology and Allergy
Immunology

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10.1111/trf.15865

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@article{693bd864be4747b4a639fa90426c670f,

title = "Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets",

abstract = "BACKGROUND: The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient-dependent factors are well described, donor-dependent variables remain poorly understood. STUDY DESIGN AND METHODS: To explore donor-dependent variables we conducted 2 retrospective studies of platelet transfusion outcomes in repeat donors. One study analyzed multiple autologous, radiolabeled platelet transfusions, and a second study analyzed multiple clinical platelet transfusions from a small cohort of repeat donors. RESULTS: In 36 subjects, multiple within-subject determinations of recovery and survival of radiolabeled autologous platelets revealed a relative consistency in platelet recoveries within donors compared to the range of recoveries among donors. Intraclass correlation coefficients for platelet recovery were 43% to 93%. In 524 ABO-compatible clinical platelet transfusions derived from seven donors, a linear mixed-effects model revealed significant donor-dependent differences in corrected count increments for units stored for 4 or 5 days. CONCLUSIONS: These two studies indicate reproducible donor-dependent differences in transfused platelet recovery, suggesting a possible heritable influence on the quality of transfused platelets.",

author = "Stefely, {Jonathan A.} and Michael Gailey and Michael Knudson and Dumont, {Larry J.} and Raife, {Thomas J.} and Samia, {Noelle I.}",

note = "Funding Information: The authors thank Mary Heintz, Louise Marsh, and Pamela Whitley for assistance with data collection. This work was supported by a UW-Madison Medical Scientist Training Program physician-scientist preceptorship via NIH MSTP T32GM008692. MPG, TJR, and NIS initiated the project. JAS, MPG, CMK, LJD, TJR, and NIS designed the study and/or performed data analysis. JAS, MPG, LJD, TJR, and NIS wrote the manuscript. Funding Information: The authors thank Mary Heintz, Louise Marsh, and Pamela Whitley for assistance with data collection. This work was supported by a UW‐Madison Medical Scientist Training Program physician‐scientist preceptorship via NIH MSTP T32GM008692. MPG, TJR, and NIS initiated the project. JAS, MPG, CMK, LJD, TJR, and NIS designed the study and/or performed data analysis. JAS, MPG, LJD, TJR, and NIS wrote the manuscript. Publisher Copyright: {\textcopyright} 2020 AABB",

year = "2020",

month = aug,

day = "1",

doi = "10.1111/trf.15865",

language = "English (US)",

volume = "60",

pages = "1837--1845",

journal = "Transfusion",

issn = "0041-1132",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets

AU - Stefely, Jonathan A.

AU - Gailey, Michael

AU - Knudson, Michael

AU - Dumont, Larry J.

AU - Raife, Thomas J.

AU - Samia, Noelle I.

N1 - Funding Information: The authors thank Mary Heintz, Louise Marsh, and Pamela Whitley for assistance with data collection. This work was supported by a UW-Madison Medical Scientist Training Program physician-scientist preceptorship via NIH MSTP T32GM008692. MPG, TJR, and NIS initiated the project. JAS, MPG, CMK, LJD, TJR, and NIS designed the study and/or performed data analysis. JAS, MPG, LJD, TJR, and NIS wrote the manuscript. Funding Information: The authors thank Mary Heintz, Louise Marsh, and Pamela Whitley for assistance with data collection. This work was supported by a UW‐Madison Medical Scientist Training Program physician‐scientist preceptorship via NIH MSTP T32GM008692. MPG, TJR, and NIS initiated the project. JAS, MPG, CMK, LJD, TJR, and NIS designed the study and/or performed data analysis. JAS, MPG, LJD, TJR, and NIS wrote the manuscript. Publisher Copyright: © 2020 AABB

PY - 2020/8/1

Y1 - 2020/8/1

N2 - BACKGROUND: The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient-dependent factors are well described, donor-dependent variables remain poorly understood. STUDY DESIGN AND METHODS: To explore donor-dependent variables we conducted 2 retrospective studies of platelet transfusion outcomes in repeat donors. One study analyzed multiple autologous, radiolabeled platelet transfusions, and a second study analyzed multiple clinical platelet transfusions from a small cohort of repeat donors. RESULTS: In 36 subjects, multiple within-subject determinations of recovery and survival of radiolabeled autologous platelets revealed a relative consistency in platelet recoveries within donors compared to the range of recoveries among donors. Intraclass correlation coefficients for platelet recovery were 43% to 93%. In 524 ABO-compatible clinical platelet transfusions derived from seven donors, a linear mixed-effects model revealed significant donor-dependent differences in corrected count increments for units stored for 4 or 5 days. CONCLUSIONS: These two studies indicate reproducible donor-dependent differences in transfused platelet recovery, suggesting a possible heritable influence on the quality of transfused platelets.

AB - BACKGROUND: The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient-dependent factors are well described, donor-dependent variables remain poorly understood. STUDY DESIGN AND METHODS: To explore donor-dependent variables we conducted 2 retrospective studies of platelet transfusion outcomes in repeat donors. One study analyzed multiple autologous, radiolabeled platelet transfusions, and a second study analyzed multiple clinical platelet transfusions from a small cohort of repeat donors. RESULTS: In 36 subjects, multiple within-subject determinations of recovery and survival of radiolabeled autologous platelets revealed a relative consistency in platelet recoveries within donors compared to the range of recoveries among donors. Intraclass correlation coefficients for platelet recovery were 43% to 93%. In 524 ABO-compatible clinical platelet transfusions derived from seven donors, a linear mixed-effects model revealed significant donor-dependent differences in corrected count increments for units stored for 4 or 5 days. CONCLUSIONS: These two studies indicate reproducible donor-dependent differences in transfused platelet recovery, suggesting a possible heritable influence on the quality of transfused platelets.

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U2 - 10.1111/trf.15865

DO - 10.1111/trf.15865

M3 - Article

C2 - 32483843

AN - SCOPUS:85085690583

SN - 0041-1132

VL - 60

SP - 1837

EP - 1845

JO - Transfusion

JF - Transfusion

IS - 8

ER -

Retrospective cohort studies of repeat donors reveal donor-dependent variability in the recovery of transfused platelets

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