Retrospective estimation and correction of physiological fluctuation in functional MRI

Xiaoping Hu*, Tuong Huu Le, Todd Parrish, Peter Erhard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

414 Scopus citations


Image‐to‐image fluctuation due to physiological motion is a major limitation to the accurate detection of neuronal activity with functional MRI. In this paper, a new and general technique for the estimation and compensation of the physiological effects is presented. By simultaneously monitoring the respiration and heart beat during the acquisition of imaging data, and retrospectively synchronizing the imaging data with physiological activity, physiological effects are estimated and removed. This technique does not rely on the periodicity of the respiration or the heart beat, does not affect the signal changes arising from neuronal activation, and is beneficial to images acquired with any speed. Experimental studies performed with FLASH and EPI sequences have demonstrated that the new technique is effective in reducing physiological fluctuation and improving the sensitivity of functional MRI and is generally applicable.

Original languageEnglish (US)
Pages (from-to)201-212
Number of pages12
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Aug 1995


  • fMRI
  • image processing
  • motion artifacts
  • physiological motion correction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Retrospective estimation and correction of physiological fluctuation in functional MRI'. Together they form a unique fingerprint.

Cite this