Retroviral proteins that interact with the host cell cytoskeleton

Mojgan H. Naghavi*, Stephen P. Goff

*Corresponding author for this work

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

In the past decade, several lines of evidence have highlighted the importance of the host cell cytoskeleton in various stages of retroviral infection. To complete their lifecycle, retroviruses must penetrate the outer barrier of the cell membrane, and viral cores containing the viral genome must traverse the cytoplasm to the nucleus and then viral gene products must make the journey back to the cell surface in order to release new progeny. The presence of a dense cytoskeletal network and organelles in the cytoplasm creates an environment that greatly impedes diffusion of macromolecules such as viruses. As such, retroviruses have evolved means to hijack actin as well as microtubule cytoskeletal networks that regulate macromolecular movement within the host cell. Developing studies are discovering several host and viral factors that play important roles in retroviral trafficking.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalCurrent Opinion in Immunology
Volume19
Issue number4
DOIs
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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