Retrovirus restriction factors

Reuben S. Harris; Rebecca S. LaRue; Thomas J. Hope

doi:10.1142/9789814295314_0013

Retrovirus restriction factors

Reuben S. Harris, Rebecca S. LaRue, Thomas J. Hope

Cell & Developmental Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

One of the major advances in the last decade of retrovirus research has been the discovery of cellular proteins that function to block viral replication. Retrovirus restriction factors such as APOBEC3G, TRIM5α and BST2 are dominant, variable, and interferon-inducible, and they have forced susceptible viruses to evolve intricate escape measures. This chapter will focus on these prototypical restriction factors and highlight several common themes.

Original language	English (US)
Title of host publication	Recent Advances in Human Retroviruses
Subtitle of host publication	Principles of Replication and Pathogenesis: Advances in Retroviral Research
Publisher	World Scientific Publishing Co.
Pages	407-437
Number of pages	31
ISBN (Electronic)	9789814295314
ISBN (Print)	9814295302, 9789814295307
DOIs	https://doi.org/10.1142/9789814295314_0013
State	Published - Jan 1 2010

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Medicine(all)

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10.1142/9789814295314_0013

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title = "Retrovirus restriction factors",

abstract = "One of the major advances in the last decade of retrovirus research has been the discovery of cellular proteins that function to block viral replication. Retrovirus restriction factors such as APOBEC3G, TRIM5α and BST2 are dominant, variable, and interferon-inducible, and they have forced susceptible viruses to evolve intricate escape measures. This chapter will focus on these prototypical restriction factors and highlight several common themes.",

author = "Harris, {Reuben S.} and LaRue, {Rebecca S.} and Hope, {Thomas J.}",

note = "Funding Information: We thank Jeremy Luban, David Sayah, and Greg Towers for critically reading the manuscript. This review was written with the support of a grant from the National Institutes of Health (R01 CA 30488). S.P.G. is an Investigator of the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2010 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.",

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AU - Harris, Reuben S.

AU - LaRue, Rebecca S.

AU - Hope, Thomas J.

N1 - Funding Information: We thank Jeremy Luban, David Sayah, and Greg Towers for critically reading the manuscript. This review was written with the support of a grant from the National Institutes of Health (R01 CA 30488). S.P.G. is an Investigator of the Howard Hughes Medical Institute. Publisher Copyright: © 2010 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.

PY - 2010/1/1

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AB - One of the major advances in the last decade of retrovirus research has been the discovery of cellular proteins that function to block viral replication. Retrovirus restriction factors such as APOBEC3G, TRIM5α and BST2 are dominant, variable, and interferon-inducible, and they have forced susceptible viruses to evolve intricate escape measures. This chapter will focus on these prototypical restriction factors and highlight several common themes.

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ER -

Retrovirus restriction factors

Abstract

ASJC Scopus subject areas

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