Renal insufficiency occurs commonly in multiple myeloma, and its presence has been considered the single most important factor in determining prognosis. Renal insufficiency has been attributed to any of these factors: hypercalcemia, hyperuricemia, increased plasma viscosity, intravenous urography (particularly after dehydration), pyelonephritis, amyloidosis, plasma cell infiltration of kidney, or intratubular precipitation of light chains ('myeloma kidney'). Patients with myeloma kidney can recover from acute renal failure. Reversal of chornic end-stage renal failure, however, has not been previously reported.
ASJC Scopus subject areas
- Internal Medicine