Abstract
An allosterically regulated, asymmetric receptor featuring a binding cavity large enough to accommodate three-dimensional pharmaceutical guest molecules as opposed to planar, rigid aromatics, was synthesized via the Weak-Link Approach. This architecture is capable of switching between an expanded, flexible "open" configuration and a collapsed, rigid "closed" one. The structure of the molecular receptor can be completely modulated in situ through the use of simple ionic effectors, which reversibly control the coordination state of the Pt(II) metal hinges to open and close the molecular receptor. The substantial change in binding cavity size and electrostatic charge between the two configurations is used to explore the capture and release of two guest molecules, dextromethorphan and β-estradiol, which are widely found as pollutants in groundwater.
Original language | English (US) |
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Pages (from-to) | 1368-1371 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 139 |
Issue number | 4 |
DOIs | |
State | Published - Feb 1 2017 |
Funding
This material is based upon work supported by the National Science Foundation award CHE-1149314, the Department of Defense National Security Science and Engineering Faculty Fellowship award N00014-15-1-0043, and the U.S. Army award W911NF-15-1-0151. J.M.A. acknowledges a fellowship from Consejo Nacional de Ciencia y Tecnologia (CONACYT). A.B.C. acknowledges a National Defense Science and Engineering Graduate Fellowship, and A.I.D. acknowledges a National Science Foundation Graduate Research Fellowship.
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry