Reversible encephalopathy after cardiac transplantation: Histologic evidence of endothelial activation, T-cell specific trafficking, and vascular endothelial growth factor expression

C. Horbinski, W. S. Bartynski, E. Carson-Walter, R. L. Hamilton, H. P. Tan, S. Cheng

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Reversible encephalopathy after transplantation is well recognized. The condition is commonly thought to be related to immune suppression, and a characteristic brain imaging pattern is typically recognized with vasogenic edema in the parietal and occipital regions, typically termed posterior reversible encephalopathy syndrome (PRES). We report the case of a patient with reversible encephalopathy after cardiac transplantation with brain biopsy evidence of endothelial activation, selective intravascular/perivascular T-cell trafficking, and VEGF expression in astrocytes, neurons, and the endothelium.

Original languageEnglish (US)
Pages (from-to)588-590
Number of pages3
JournalAmerican Journal of Neuroradiology
Volume30
Issue number3
DOIs
StatePublished - Mar 2009

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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