Reversibly addressing an allosteric catalyst in situ: Catalytic molecular tweezers

Nathan C. Gianneschi, So Hye Cho, Son Binh T. Nguyen, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

Abiotic allosteric regulation: The design, synthesis, and application of novel, reversible allosteric catalytic molecular tweezers that contain a structural metal, addressable in situ, and two functional catalytic metals are reported (see picture). Kinetic and selectivity data reflect a significant decrease in cooperativity upon opening of the "arms" of the catalyst caused by reactions occurring at the hinge.

Original languageEnglish (US)
Pages (from-to)5503-5507
Number of pages5
JournalAngewandte Chemie - International Edition
Volume43
Issue number41
DOIs
StatePublished - Oct 18 2004

Keywords

  • Asymmetric catalysis
  • Coordination chemistry
  • Ligand design
  • Ligand effect
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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