Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

Jingwei Ma; Yi Zhang; Ke Tang; Huafeng Zhang; Xiaonan Yin; Yong Li; Pingwei Xu; Yanling Sun; Ruihua Ma; Tiantian Ji; Junwei Chen; Shuang Zhang; Tianzhen Zhang; Shunqun Luo; Yang Jin; Xiuli Luo; Chengyin Li; Hongwei Gong; Zhixiong Long; Jinzhi Lu; Zhuowei Hu; Xuetao Cao; Ning Wang; Xiangliang Yang; Bo Huang

doi:10.1038/cr.2016.53

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

Jingwei Ma, Yi Zhang, Ke Tang, Huafeng Zhang, Xiaonan Yin, Yong Li, Pingwei Xu, Yanling Sun, Ruihua Ma, Tiantian Ji, Junwei Chen, Shuang Zhang, Tianzhen Zhang, Shunqun Luo, Yang Jin, Xiuli Luo, Chengyin Li, Hongwei Gong, Zhixiong Long, Jinzhi LuZhuowei Hu, Xuetao Cao, Ning Wang, Xiangliang Yang, Bo Huang^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

189 Scopus citations

Abstract

Developing novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to improve outcomes of cancer patients. Here we show an innovative approach that reverses drug resistance of TRCs using tumor cell-derived microparticles (T-MPs) containing anti-tumor drugs. TRCs, by virtue of being more deformable than differentiated cancer cells, preferentially take up T-MPs that release anti-tumor drugs after entering cells, which in turn lead to death of TRCs. The underlying mechanisms include interfering with drug efflux and promoting nuclear entry of the drugs. Our findings demonstrate the importance of tumor cell softness in uptake of T-MPs and effectiveness of a novel approach in reversing drug resistance of TRCs with promising clinical applications.

Original language	English (US)
Pages (from-to)	713-727
Number of pages	15
Journal	Cell Research
Volume	26
Issue number	6
DOIs	https://doi.org/10.1038/cr.2016.53
State	Published - Jun 1 2016

Keywords

drug resistance
drug-packaging microparticles
nuclear delivery
tumor-repopulating cells

ASJC Scopus subject areas

Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/cr.2016.53

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Ma, J., Zhang, Y., Tang, K., Zhang, H., Yin, X., Li, Y., Xu, P., Sun, Y., Ma, R., Ji, T., Chen, J., Zhang, S., Zhang, T., Luo, S., Jin, Y., Luo, X., Li, C., Gong, H., Long, Z., ... Huang, B. (2016). Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Research, 26(6), 713-727. https://doi.org/10.1038/cr.2016.53

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title = "Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles",

abstract = "Developing novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to improve outcomes of cancer patients. Here we show an innovative approach that reverses drug resistance of TRCs using tumor cell-derived microparticles (T-MPs) containing anti-tumor drugs. TRCs, by virtue of being more deformable than differentiated cancer cells, preferentially take up T-MPs that release anti-tumor drugs after entering cells, which in turn lead to death of TRCs. The underlying mechanisms include interfering with drug efflux and promoting nuclear entry of the drugs. Our findings demonstrate the importance of tumor cell softness in uptake of T-MPs and effectiveness of a novel approach in reversing drug resistance of TRCs with promising clinical applications.",

keywords = "drug resistance, drug-packaging microparticles, nuclear delivery, tumor-repopulating cells",

author = "Jingwei Ma and Yi Zhang and Ke Tang and Huafeng Zhang and Xiaonan Yin and Yong Li and Pingwei Xu and Yanling Sun and Ruihua Ma and Tiantian Ji and Junwei Chen and Shuang Zhang and Tianzhen Zhang and Shunqun Luo and Yang Jin and Xiuli Luo and Chengyin Li and Hongwei Gong and Zhixiong Long and Jinzhi Lu and Zhuowei Hu and Xuetao Cao and Ning Wang and Xiangliang Yang and Bo Huang",

year = "2016",

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Ma, J, Zhang, Y, Tang, K, Zhang, H, Yin, X, Li, Y, Xu, P, Sun, Y, Ma, R, Ji, T, Chen, J, Zhang, S, Zhang, T, Luo, S, Jin, Y, Luo, X, Li, C, Gong, H, Long, Z, Lu, J, Hu, Z, Cao, X, Wang, N, Yang, X & Huang, B 2016, 'Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles', Cell Research, vol. 26, no. 6, pp. 713-727. https://doi.org/10.1038/cr.2016.53

TY - JOUR

T1 - Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

AU - Ma, Jingwei

AU - Zhang, Yi

AU - Tang, Ke

AU - Zhang, Huafeng

AU - Yin, Xiaonan

AU - Li, Yong

AU - Xu, Pingwei

AU - Sun, Yanling

AU - Ma, Ruihua

AU - Ji, Tiantian

AU - Chen, Junwei

AU - Zhang, Shuang

AU - Zhang, Tianzhen

AU - Luo, Shunqun

AU - Jin, Yang

AU - Luo, Xiuli

AU - Li, Chengyin

AU - Gong, Hongwei

AU - Long, Zhixiong

AU - Lu, Jinzhi

AU - Hu, Zhuowei

AU - Cao, Xuetao

AU - Wang, Ning

AU - Yang, Xiangliang

AU - Huang, Bo

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Developing novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to improve outcomes of cancer patients. Here we show an innovative approach that reverses drug resistance of TRCs using tumor cell-derived microparticles (T-MPs) containing anti-tumor drugs. TRCs, by virtue of being more deformable than differentiated cancer cells, preferentially take up T-MPs that release anti-tumor drugs after entering cells, which in turn lead to death of TRCs. The underlying mechanisms include interfering with drug efflux and promoting nuclear entry of the drugs. Our findings demonstrate the importance of tumor cell softness in uptake of T-MPs and effectiveness of a novel approach in reversing drug resistance of TRCs with promising clinical applications.

AB - Developing novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to improve outcomes of cancer patients. Here we show an innovative approach that reverses drug resistance of TRCs using tumor cell-derived microparticles (T-MPs) containing anti-tumor drugs. TRCs, by virtue of being more deformable than differentiated cancer cells, preferentially take up T-MPs that release anti-tumor drugs after entering cells, which in turn lead to death of TRCs. The underlying mechanisms include interfering with drug efflux and promoting nuclear entry of the drugs. Our findings demonstrate the importance of tumor cell softness in uptake of T-MPs and effectiveness of a novel approach in reversing drug resistance of TRCs with promising clinical applications.

KW - drug resistance

KW - drug-packaging microparticles

KW - nuclear delivery

KW - tumor-repopulating cells

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JF - Cell Research

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ER -

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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