Review: 5-fluorouracil cardiotoxicity: A critical review

W. J. Gradishar*, E. E. Vokes

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


5-Fluorouracil is a commonly administered chemotherapy agent that has infrequently been associated with cardiotoxicity. This review highlights the clinical features of this syndrome as described in reports from the medical literature. Clinical and laboratory evidence supporting proposed underlying mechanisms are reviewed.

Original languageEnglish (US)
Pages (from-to)409-414
Number of pages6
JournalAnnals of Oncology
Issue number6
StatePublished - Nov 1990


  • 5-Fluorouracil
  • Angina
  • Coronary spasm
  • Myocardial infarction
  • Thrombosis
  • Toxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology


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