@article{20131f16c57d4f458d6f6dbebd83e2d3,
title = "Review article: current and future treatment approaches for IBS with constipation",
abstract = "Background: Multiple efficacious therapies are currently available for treating irritable bowel syndrome with constipation (IBS-C). IBS-C specific survey tools that assess symptom relief, treatment satisfaction, and quality of life are important for gauging real-world effectiveness. Aims/Methods: This article reviews clinical trial efficacy data as well as survey data on adequate relief and quality of life from pivotal trials for lubiprostone, linaclotide, plecanatide, tenapanor, and tegaserod. A brief discussion of agents in development with novel mechanisms of action is also provided. Results/Conclusions: Quality of life and symptom metrics should be standardized and continue to be represented in future IBS-C trials. The choice of agent should be tailored to probability of improving symptoms, safety, tolerability, and cost.",
author = "Liu, {Joy J.} and Brenner, {Darren M.}",
note = "Funding Information: : Darren M. Brenner has served as a speaker, a consultant or an advisory board member for Allergan (Abbvie), Ironwood, Salix, Takeda, Redhill, Arena, Alfasigma and Alnylam Pharmaceuticals. He has received unrestricted research funding from the Irene D. Pritzker Foundation. Joy J. Liu has no financial disclosures to report. Declaration of personal interests Funding Information: No funding was provided to support the preparation of this manuscript. Declaration of personal interests: Darren M. Brenner has served as a speaker, a consultant or an advisory board member for Allergan (Abbvie), Ironwood, Salix, Takeda, Redhill, Arena, Alfasigma and Alnylam Pharmaceuticals. He has received unrestricted research funding from the Irene D. Pritzker Foundation. Joy J. Liu has no financial disclosures to report. Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Ltd",
year = "2021",
month = dec,
doi = "10.1111/apt.16607",
language = "English (US)",
volume = "54",
pages = "S53--S62",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Wiley-Blackwell",
number = "S1",
}