Review article: The medical management of Crohn's disease

E. Elton, S. B. Hanauer*

*Corresponding author for this work

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

The choice of medical therapies for Crohn's disease continues to grow, Although our understanding of the mechanisms of the disease is incomplete, increasing knowledge of the pathogenesis of inflammation in general and Crohn's disease in particular allows targeting of therapies at various points in the immunoinflammatory cascade. In addition, the,division of Crohn's disease into subtypes by location, aggressiveness, and the presence or absence of perianal and fistulizing disease allows the tailoring of medical therapy to the individual patient. For those patients with moderate to severe symptoms or frequent flares of disease activity, and those who have required surgical resection, maintenance therapy can substantially reduce the rate of recurrence. Despite these advances, available medical therapies for Crohn's disease remain imperfect, as evidenced by their sometimes substantial toxicities and the continued frequent need for surgery.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalAlimentary Pharmacology and Therapeutics
Volume10
Issue number1
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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