Review of Critical Illness Myopathy and Neuropathy

Starane Shepherd, Ayush Batra, David P Lerner

Research output: Contribution to journalArticlepeer-review


Critical illness myopathy (CIM) and neuropathy are underdiagnosed conditions within the intensive care setting and contribute to prolonged mechanical ventilation and ventilator wean failure and ultimately lead to significant morbidity and mortality. These conditions are often further subdivided into CIM, critical illness polyneuropathy (CIP), or the combination-critical illness polyneuromyopathy (CIPNM). In this review, we discuss the epidemiology and pathophysiology of CIM, CIP, and CIPNM, along with diagnostic considerations such as detailed clinical examination, electrophysiological studies, and histopathological review of muscle biopsy specimens. We also review current available treatments and prognosis. Increased awareness and early recognition of CIM, CIP, and CIPNM in the intensive care unit setting may lead to earlier treatments and rehabilitation, improving patient outcomes.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalThe Neurohospitalist
Issue number1
StatePublished - Jan 2017


  • Journal Article

Fingerprint Dive into the research topics of 'Review of Critical Illness Myopathy and Neuropathy'. Together they form a unique fingerprint.

Cite this