Review: Recovery from Spinal Cord Injury: New Approaches

Laising Yen, Robert G. Kalb*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Damage to the spinal cord has devastating consequences because injury induces neuronal death, and the severed neural pathway does not regenerate. One of the major challenges in this field is to rescue injured neurons and to stimulate the regrowth of severed axons. An equally important task is the re-establishment of precise connections by regenerating axons with their targets and remyelinating the regenerated axons so that they can propagate action potentials. In our view, the major hurdles that must be overcome to restore function after spinal cord injury can be viewed as a recapitulation of steps normally taken during development. Recent basic research advances provide cautious optimism that therapies will be available for acute and chronic spinal cord injury.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalThe Neuroscientist
Volume1
Issue number6
DOIs
StatePublished - Jan 1 1995

Keywords

  • Activity-dependent plasticity
  • Axonal regeneration
  • Cell death
  • KEY WORDS Trophic factors
  • Myelination
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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