Revision to the origins of the mononuclear phagocyte

Carla M. Cuda; Harris R Perlman

doi:10.1016/B978-0-443-23947-2.00047-3

Revision to the origins of the mononuclear phagocyte

Carla M. Cuda, Harris R Perlman

Medicine, Rheumatology Division

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Numerous types of cells form the category of “innate immune cells,” including basophils, eosinophils, mast cells, dendritic cells, neutrophils, monocytes, and macrophages. These cells arise from a common myeloid progenitor and diverge after this stage into their specific compartments. Over the past 15 years, the origins of the mononuclear phagocyte system, that is, tissue-resident macrophages and monocytes, have undergone a massive revision. Here, we elaborate on the highly controversial origin of tissue-resident macrophages.

Original language	English (US)
Title of host publication	The Rose and Mackay Textbook of Autoimmune Diseases, Seventh Edition
Publisher	Elsevier
Pages	15-26
Number of pages	12
ISBN (Electronic)	9780443239472
ISBN (Print)	9780443239465
DOIs	https://doi.org/10.1016/B978-0-443-23947-2.00047-3
State	Published - Jan 1 2024

Keywords

heterogeneity
Tissue-resident macrophage
transcriptional profiling

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

Access to Document

10.1016/B978-0-443-23947-2.00047-3

Cite this

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AB - Numerous types of cells form the category of “innate immune cells,” including basophils, eosinophils, mast cells, dendritic cells, neutrophils, monocytes, and macrophages. These cells arise from a common myeloid progenitor and diverge after this stage into their specific compartments. Over the past 15 years, the origins of the mononuclear phagocyte system, that is, tissue-resident macrophages and monocytes, have undergone a massive revision. Here, we elaborate on the highly controversial origin of tissue-resident macrophages.

KW - heterogeneity

KW - Tissue-resident macrophage

KW - transcriptional profiling

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EP - 26

BT - The Rose and Mackay Textbook of Autoimmune Diseases, Seventh Edition

PB - Elsevier

ER -

Revision to the origins of the mononuclear phagocyte

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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